Toxicological and hygienic assessment of phthalate content in bottled drinking water

V. Shilov, O. Khurtsilava, O. Markova, D. S. Isaev, Alena Yuryevna Mikheeva
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Abstract

Introduction. One of the most common materials containing phthalate impurities is packaging made of polymer materials (bottles). Bottles made of the following material are used for packaged (bottled) drinking water - polyethylene terephthalate (PET). The toxicological properties of phthalates, the increase in consumption of bottled water and uncertainty about the effect of storage conditions on the migration of phthalates into water initiates research on the toxicological and hygienic assessment of the content of phthalates in polymer packaging for bottled drinking water.The purpose of study was the toxicological and hygienic assessment of the content of di(2-ethylhexyl)-phthalate (DEHP); di-n-butyl phthalate (DnBP); diisobutyl phthalate (DiBP) in drinking water packed in polymer material. Materials and methods. The objects of the study were bottles samples made in the Russian Federation. The obtained extracts (containers and model medium) were analyzed by gas chromatography with mass spectrometric detection. The values of daily consumption of phthalates with bottled water for adults and children were calculated, safety coefficients were determined taking into account the maximum concentrations obtained in the experiment. Results. As a result of polymer materials studies, it was found that bottle samples contain residual amounts of phthalates – DEHP 1.7–4.2 mg/kg; DnBP <2.4–31.3 mg/kg; DiBP 2.2–10.2 2 mg/kg. Migration of phthalates into aqueous model media was noted from all the samples studied.In the samples of model solutions in contact with PET material, on the 30th day at a temperature of 20 °C, the presence of 2 phthalates: DEHP 8.6–71.0 µ/l and DiBF <2.6 to 19.2 µ/l. Comparison of phthalate concentrations in model media with the values of permissible daily consumption showed that bottled water provides a limited contribution to the total daily exposure of phthalates. Conclusion. The study results showed that the packaging made of PET is a source of chemical contamination of bottled water, which is based on the processes of migration of organic components from polymer materials. At the same time, special attention should be paid to the ability to migrate di(2-ethylhexyl)-phthalate, which can lead to excess of hygienic standards for drinking water.
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瓶装饮用水中邻苯二甲酸盐含量的毒理学和卫生评价
介绍。最常见的含有邻苯二甲酸盐杂质的材料之一是由聚合物材料(瓶子)制成的包装。以下材料制成的瓶子用于包装(瓶装)饮用水-聚对苯二甲酸乙二醇酯(PET)。邻苯二甲酸盐的毒理学特性、瓶装水消费量的增加以及储存条件对邻苯二甲酸盐向水中迁移的影响的不确定性,引发了对瓶装饮用水聚合物包装中邻苯二甲酸盐含量的毒理学和卫生评估的研究。研究目的是对邻苯二甲酸二(2-乙基己基)酯(DEHP)含量进行毒理学和卫生学评价;邻苯二甲酸二丁酯(DnBP);高分子材料包装饮用水中的邻苯二甲酸二异丁酯(DiBP)。材料和方法。研究对象是俄罗斯联邦生产的瓶子样品。所得提取物(容器和模型介质)采用气相色谱-质谱检测进行分析。计算了成人和儿童每天饮用瓶装水时邻苯二甲酸盐的摄取量,并根据实验中得到的最大浓度确定了安全系数。结果。高分子材料研究结果发现,瓶样中邻苯二甲酸酯残留量- DEHP 1.7-4.2 mg/kg;DnBP <2.4 ~ 31.3 mg/kg;DiBP 2.2-10.2 mg/kg。从所有研究的样品中都注意到邻苯二甲酸盐向水模型介质的迁移。在与PET材料接触的模型溶液样品中,在温度为20°C的条件下,第30天,存在2种邻苯二甲酸盐:DEHP 8.6-71.0µ/l和DiBF <2.6 - 19.2µ/l。将模型介质中的邻苯二甲酸盐浓度与允许的每日消费量进行比较,结果表明瓶装水对邻苯二甲酸盐每日暴露总量的贡献有限。结论。研究结果表明,PET包装是瓶装水化学污染的一个来源,这是基于聚合物材料中有机成分迁移的过程。同时,应特别注意邻苯二甲酸二(2-乙基己基)-邻苯二甲酸酯的迁移能力,这可能导致饮用水卫生标准超标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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