The Effectiveness of Green Grape Extract (Vitis vinifera) on Decreasing White Rat (Rattus novergicus) Triglycerides Levels

Journal of Muhammadiyah Medical Laboratory Technologist Pub Date : 2022-06-02 DOI:10.24853/mmj.3.1.1-9

Ketut Lilik Arwati, Ni Nyoman Ayu Dewi, H. Bekti, Ni Wayan Sucindra Dewi, Andi Udin Saransi

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引用次数: 1

Abstract

Background: Grapes (Vitis vinifera) are a source of antioxidants with high content of polyphenols and anthocyanins. Grape skin is rich in flavonoids. Anthocyanins and flavonoids have the effect of lowering blood triglyceride levels. Purposes: This study aimed to determine the effect of using green grape extract (GGE) in lowering triglyceride levels in the blood. Methods: Five groups of white male rats (Rattus novergicus) were divided into a negative control group (KN), positive control (KP), rats with a GGE dose of 100 mg/200g BW as P1, rats with a GGE dose of 250mg/200g BW as P2, and rats with GGE dose of 500 mg/200g BW as P3. Each group was given a hypercholesterolemic diet for five weeks. Groups P1, P2, and P3 were given GGE according to their respective doses for 14 days, then measured triglyceride levels in the blood. Results: The results showed that GGE 500mg/200g BW significantly reduced triglyceride levels in all treated mice. Conclusion: These results indicate that GGE has a great potential to treat dyslipidemia by lowering triglyceride levels in the blood.

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绿葡萄提取物降低白鼠甘油三酯水平的研究

背景:葡萄(Vitis vinifera)是富含多酚和花青素的抗氧化剂的来源。葡萄皮富含类黄酮。花青素和类黄酮具有降低血液甘油三酯水平的作用。目的:本研究旨在确定使用绿葡萄提取物(GGE)在降低血液中甘油三酯水平的影响。方法:将5组白色雄性大鼠(Rattus novergicus)分为阴性对照组(KN)、阳性对照组(KP)、GGE剂量为100 mg/200g BW的大鼠为P1、GGE剂量为250mg/200g BW的大鼠为P2、GGE剂量为500 mg/200g BW的大鼠为P3。每组给予高胆固醇饮食5周。P1、P2、P3组按剂量给予GGE治疗14 d，测定血液中甘油三酯水平。结果:GGE 500mg/200g BW显著降低各组小鼠甘油三酯水平。结论:GGE通过降低血液中甘油三酯水平来治疗血脂异常具有很大的潜力。

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Journal of Muhammadiyah Medical Laboratory Technologist

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24 weeks