Progress on the Enantioselective Synthesis of Axially Chiral Cycloalkylidenes

Abstract

The discovery of new asymmetric synthetic methodologies and the asymmetric synthesis of new chiral compounds have been the central work of synthetic organic chemists for decades. Axially chiral compounds have gained considerable attention in recent years because of their unique utility in asymmetric catalysis and synthesis. The asymmetric synthesis of axially chiral cycloalkylidenes, a subset of axial chirality molecules, is sluggish compared to chiral allenes, and chiral biaryl compounds. In this review, different approaches for the synthesis of axially chiral cycloalkylidenes are summarized.