Three bisabolane sesquiterpenoids and a phenolic derivative from the fungus Stereum hirsutum

Qin LI, Aimin FU, Chunmei CHEN, Fei LIU, Mengsha WEI, Hucheng ZHU, Yonghui ZHANG
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Abstract

Objective

To explore the secondary metabolites of the higher fungus Stereum hirsutum.

Methods

The structures of these compounds were elucidated by extensive spectroscopic analyses and NMR calculations.

Results

Three new bisabolane sesquiterpenoids, sterene acids A–C (1–3), and one new phenolic derivative, sterephenol A (4), were isolated from the higher fungus S. hirsutum.

Conclusion

Compound 1 is the first example of bisabolane sesquiterpenoid bearing an allene group. It is also the first time to discover bisabolane sesquiterpenoids from the fungus S. hirsutum.

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三种双甾烷倍半萜和一种从真菌中提取的酚类衍生物
目的探讨高等真菌毛体菌的次生代谢产物。方法通过广泛的波谱分析和核磁共振计算对化合物的结构进行鉴定。结果从高等真菌中分离到3个新的双甾烷倍半萜类化合物甾酸A - c(1-3)和1个新的酚类衍生物甾酚A(4)。结论化合物1是首个含烯基双abolane倍半萜类化合物。这也是首次从真菌中发现双甾烷倍半萜。
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