Discovering Capacity in Novel Targets: C. Elegans as a Model Life Form in Toxicological Research

Destefani Ac, Costa Ds, Zanardo Tec, Taufner Gh
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引用次数: 2

Abstract

The nematode Caenorhabditis elegans has risen as a critical creature show in different fields including neurobiology, formative science, and hereditary qualities. Qualities of this creature demonstrate that have added to its prosperity incorporate its hereditary manipulability, invariant and completely depicted formative program, all around portrayed genome, simplicity of support, short and productive life cycle, and little body estimate. These same elements have prompted to an expanding utilization of C. elegans in toxicology, both for robotic reviews and highthroughput screening approaches. We depict a portion of the exploration that has been completed in the territories of neurotoxicology, hereditary toxicology, and ecological toxicology, and additionally high-throughput tries different things with C. elegans including all inclusive screening for sub-atomic focuses of harmfulness and fast danger evaluation for new chemicals. We contend for an expanded part for C. elegans in supplementing other model frameworks in toxicological research.
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发现新目标的能力:秀丽隐杆线虫作为毒理学研究中的模式生命形式
秀丽隐杆线虫(Caenorhabditis elegans)已成为神经生物学、形成科学、遗传特性等多个领域的重要生物。这种生物的特质表明,它的遗传可操纵性、不变和完全描绘的形成程序、周围描绘的基因组、简单的支持、短而多产的生命周期和小的身体估计,都增加了它的繁荣。这些相同的因素促使秀丽隐杆线虫在毒理学中的应用不断扩大,无论是机器人审查还是高通量筛选方法。我们描述了在神经毒理学、遗传毒理学和生态毒理学领域已经完成的部分探索,并对秀丽隐杆线虫进行了高通量的不同尝试,包括对亚原子有害焦点的全面筛选和对新化学品的快速危险评估。我们主张在毒理学研究中为秀丽隐杆线虫补充其他模型框架的扩展部分。
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