Forearm Compartment Syndrome in a Two-year-old Boy with Severe Hemophilia A and High Titer Inhibitor Factor VIII: A Case Report

Abstract

We present a case of a two-year-old boy with hemophilia A and high titer factor inhibitor, who developed forearm compartment syndrome two days after taking blood samples for a regular check-up of serum concentration of Factor VIII. Emergency fasciotomy was performed to prevent Volkmann contracture. The patient needed bypass therapies including recombitant activated factor VII (rFVIIa), activated prothrombin complexes (aPCC), factors VII・X (MC7-10), and transfusions. Eleven days after the surgical intervention, he was discharged without any functional loss in the affected upper extremity. Early surgical intervention prevented compartment syndrome of affected upper extreme.