{"title":"Sandpaper and Topical 5-Fluorouracil: A Different Therapeutic Modality for Acral Vitiligo","authors":"Eman Asker, G. Mohammed, A. H. Gomaa, M. Eyada","doi":"10.20431/2456-0022.0401001","DOIUrl":null,"url":null,"abstract":"Acral vitiligo (AV) is resistant to treatment [1, 2]. There are many factors help in developing this resistance. Low density of pilosebaceous follicles, melanocyte, melanocyte stem cell reservoirs, baseline epidermal stem cell factor from which the melanocytes could migrate, lower stem cell factor (SCF), c-kit, MHCII expression as well as lower density of Langerhans cells (LC), and high rate of koebnerization are playing roles in resistance of acral lesions [1,3,4]","PeriodicalId":8208,"journal":{"name":"ARC Journal of Dermatology","volume":"21 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ARC Journal of Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20431/2456-0022.0401001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Acral vitiligo (AV) is resistant to treatment [1, 2]. There are many factors help in developing this resistance. Low density of pilosebaceous follicles, melanocyte, melanocyte stem cell reservoirs, baseline epidermal stem cell factor from which the melanocytes could migrate, lower stem cell factor (SCF), c-kit, MHCII expression as well as lower density of Langerhans cells (LC), and high rate of koebnerization are playing roles in resistance of acral lesions [1,3,4]
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