Isolation of Nimbolide from Azadirachta Indica Assisted by Molecular Docking as an Antiproliferative Agent

Abstract

The Cancer is defined as abnormal and repetitive growth of the cell on various region of the body, Chemotherapy is a much of the time utilized treatment for cancer which include medicines (drugs) like carboplatin, 5-fluorouracil, paclitaxel, cisplatin, topotecan, cyclophosphamide, irinitecan, gemcitabine, docetaxel, doxorubicin and mitomycin. The above Drugs have certain toxicities such as Nephrotoxicity, Hepatotoxicity, Anemia, Thrombocytopenia, Leucopenia, Degeneration of hair follicle etc, Because of the low therapeutic index, the drugs degenerate normal cells with cancerous cells, Thus it is necessary to develop the medication and therapy to reduce this cytotoxic effects, This can be achieve by using natural and safe agents for the treatment of cancer. In this point of view some phytochemical constituents were recognized, for example, taxol, vincristine, and vinblastine [1-2]. There is expanding number of distributions on Azadirachta indica and its concentrate to battle against various tumors. Azadirachta indica is evergreen, tropical, having angled molded green leaves and trunk of timber with bug repellent properties. Generally, Azadirachta indica demonstrated an anticancer movement by advancing the cell reinforcement chemical, and adjusting the intracellular segments fundamental for tumor development and advancement, for example, Cyclin D, Cyclin B, Cyclin B1, Cyclin1, Cyclin E, P53, PCNA, P21,GST-P. Nimbolide was found to bind with the cell cycle energy in cancer cells by inhensing the cell cycle capture at G1/S or G2/M stage through concealment of Cyclin, CDKs and PCNA [3-6].