Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis.

IF 0.8 1区文学 0 LANGUAGE & LINGUISTICS Natural Language & Linguistic Theory Pub Date : 2022-03-26 eCollection Date: 2022-01-01 DOI:10.1155/2022/1144563

Chenyang Lei, Juan Jiang, Yanyan Zhang, Gaoyun Xiong

引用次数: 0

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis characterized by high edema in the stroma, albumin deposition, and formation of pseudocysts. The pathogenesis of CRSwNP is not yet fully understood. Regulatory T (Treg) cells are a subset of CD4+ T cells that play a suppressive immunoregulatory role in the process of CRSwNP. Recent studies have found that there was a significant reduction in Treg cells in polyp tissues, which leads to the onset of CRSwNP. An imbalance between Th17 and Treg cells can also aggravate inflammation toward the Th2 type. This review focuses on our understanding of the function and role of Treg cells and their regulatory factors and clinical significance in CRSwNP. We also summarize the current drug treatments for CRSwNP with Tregs as the potential therapeutic target, which will provide new ideas for the treatment of CRSwNP in the future.

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调节性 T 细胞在慢性鼻炎伴鼻息肉病中的作用和功能

慢性鼻炎伴鼻息肉（CRSwNP）是慢性鼻炎的一种亚型，其特点是鼻腔基质高度水肿、白蛋白沉积和假性囊肿的形成。CRSwNP 的发病机制尚不完全清楚。调节性 T（Treg）细胞是 CD4+ T 细胞的一个亚群，在 CRSwNP 的发病过程中起到抑制免疫调节的作用。最近的研究发现，息肉组织中的 Treg 细胞明显减少，从而导致 CRSwNP 的发生。Th17 细胞和 Treg 细胞之间的失衡也会使炎症向 Th2 型发展。本综述重点介绍我们对 Treg 细胞的功能和作用及其在 CRSwNP 中的调节因子和临床意义的理解。我们还总结了目前以 Tregs 为潜在治疗靶点的 CRSwNP 药物治疗方法，这将为今后治疗 CRSwNP 提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Language & Linguistic Theory Multiple-

CiteScore

3.00

自引率

7.70%

发文量

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