Assessing Performance of Martins's and Sampson's Formulae for Calculation of LDL-C in Indian Population: A Single Center Retrospective Study.

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Indian Journal of Clinical Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-07-07 DOI:10.1007/s12291-023-01142-3
Shrimanjunath Sankanagoudar, Sojit Tomo, Andystar Syiemlieh, Prem Prakash Sharma, Mithu Banerjee, Praveen Sharma
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Abstract

Various formulae had been derived to calculate the LDL-C from other lipid profile parameters to supplant the need for direct estimation. Martin's, Sampson's, and Cordova's formulae are recently derived formulae for calculating LDL-C. However, no study has been undertaken till now to verify the newer formulae viz. Martins's and Sampson's in Indian population. The retrospective cross-sectional study was carried out after obtaining approval from the Institutional Ethics Committee on human subject research. The lipid profile data were collected for a period of 17 months from January 2020 to May 2021. The formulae proposed by Friedewald, Cordova, Anandaraja, Martin, and Sampson were used to assess calculated LDL-C. Intraclass correlations were performed to assess the effectiveness of each formula when compared with direct estimation. In our study, we observed that LDL-C calculated using Martin was observed to be closer to that of direct estimation. The bias observed was lowest for Martin's formulae, followed by Sampson's. Intraclass correlation analysis for absolute agreement demonstrated Cordova, Martin, and Sampson to have an average ICC > 0.9, with Martin, and Sampson having a p value < 0.05. Martin fared superior to other formulae in intraclass correlation in patients with LDL > 70. In patients with TG below 200 mg/dL, Martin, and Sampson had a significant correlation with comparable average ICC. However, in patients with TG > 300 mg/dL, Cordova appears to fare better than all other formulae. Our study demonstrated a distinctly superior performance of Martin's formula over Friedewald's formula in the Indian patient population.

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评估马丁斯公式和桑普森公式在印度人群中计算低密度脂蛋白胆固醇的性能:单中心回顾性研究
为了取代直接估算的需要,人们推导出了各种公式,根据其他血脂特征参数计算低密度脂蛋白胆固醇。马丁公式、桑普森公式和科尔多瓦公式是最近推导出的低密度脂蛋白胆固醇计算公式。然而,迄今为止还没有研究在印度人群中验证较新的公式,即马丁斯公式和桑普森公式。这项回顾性横断面研究是在获得人体研究机构伦理委员会批准后进行的。从 2020 年 1 月到 2021 年 5 月,共收集了 17 个月的血脂数据。弗里德瓦尔德(Friedewald)、科尔多瓦(Cordova)、阿南达拉贾(Anandaraja)、马丁(Martin)和桑普森(Sampson)提出的公式用于评估计算出的低密度脂蛋白胆固醇。通过类内相关性来评估每种公式与直接估算法相比的有效性。在我们的研究中,我们发现使用马丁公式计算出的 LDL-C 更接近直接估算值。马丁公式的偏差最小,桑普森公式次之。绝对一致的类内相关分析表明,科尔多瓦、马丁和桑普森的平均 ICC > 0.9,马丁和桑普森的 P 值为 70。在总胆固醇低于 200 毫克/分升的患者中,马丁和桑普森具有显著的相关性,平均 ICC 值相当。然而,在总胆固醇大于 300 毫克/分升的患者中,Cordova 似乎优于所有其他公式。我们的研究表明,在印度患者群体中,马丁公式的性能明显优于弗里德瓦尔德公式。
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来源期刊
Indian Journal of Clinical Biochemistry
Indian Journal of Clinical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
4.50
自引率
4.80%
发文量
74
期刊介绍: The primary mission of the journal is to promote improvement in the health and well-being of community through the development and practice of clinical biochemistry and dissemination of knowledge and recent advances in this discipline among professionals, diagnostics industry, government and non-government organizations. Indian Journal of Clinical Biochemistry (IJCB) publishes peer reviewed articles that contribute to the existing knowledge in all fields of Clinical biochemistry, either experimental or theoretical, particularly deal with the applications of biochemistry, molecular biology, genetics, biotechnology, and immunology to the diagnosis, treatment, monitoring and prevention of human diseases. The articles published also include those covering the analytical and molecular diagnostic techniques, instrumentation, data processing, quality assurance and accreditation aspects of the clinical investigations in which chemistry has played a major role, or laboratory animal studies with biochemical and clinical relevance.
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