Hepatoprotective Effect of Herbal Medicinal Plant Extract against Paracetamol Induced Liver Injury in Rats

International Journal of Medical and Biomedical Studies Pub Date : 2023-04-03 DOI:10.32553/ijmbs.v7i4.2689

Pawan Sharma, V. Nakra, Vidhi Jain, Manmeet Singh Saluja

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Abstract

The purpose of this study was to examine the hepatoprotective efficacy of Whole plant extract of Adiantum capillus against Paracetamol induced liver damage in rats. Wistar albino rats were orally fed 500 mg/kg of body weight of Methanolic and Acetonic extract of Adiantum capillus Whole plant, with Silymarin serving as the reference. By restoring functional parameters, physical parameters, biochemical parameters, and decreasing blood enzymes alkaline phosphatase (ALP) and total bilirubin (TBL) in the selected animal, the methanolic and Acetonic extracts exhibited a potent hepatoprotective effect. The plant's chemical composition includes, among others, alkaloids, flavonoids, glycosides, steroids, terpenoids, phenolics, and saponins. The overall experimental data suggest that bioactive phytoconstituents, such as flavonoids and alkaloids, present in the Methanolic and Acetonic extracts of Adiantum capillus plant may be responsible for the plant's significant hepatoprotective effect. The results thus support the use of Adiantum capillus plant as a hepatoprotectant.

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植物提取物对扑热息痛所致大鼠肝损伤的保护作用

本研究旨在探讨毛茛全植物提取物对扑热息痛致大鼠肝损伤的保护作用。以水飞蓟素为参比，以500 mg/kg体重灌胃白化Wistar大鼠。通过恢复所选动物的功能参数、物理参数、生化参数，降低血酶碱性磷酸酶(ALP)和总胆红素(TBL)，甲醇和丙酮提取物显示出强有力的肝保护作用。这种植物的化学成分包括生物碱、类黄酮、糖苷、类固醇、萜类、酚类和皂苷等。综上所述，毛茛的甲醇和丙酮提取物中含有的黄酮类和生物碱等活性成分可能是毛茛具有显著的保肝作用的主要原因。本研究结果支持毛茛作为肝保护剂的应用。

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International Journal of Medical and Biomedical Studies

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