Inflammasomes: Role in Disease Pathogenesis and Therapeutic Potential

E. Garanina, E. Martynova, K. Ivanov, A. Rizvanov, S. Khaiboullina
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Abstract

The structure of inflammasomes, history of their discovery, and their potential use as therapeutic targets were discussed. Inflammasomes represent cytosolic polyprotein complexes that are formed in response to various external and internal stimuli, including viral and bacterial infections. The main products of inflammasomes are pro-inflammatory cytokines: interleukin-1-beta (IL-1β) and interleukin-18 (IL-18). Both cytokines are formed through proteolytic cleavage by active caspase-1. Caspase-1 activation leads to a special form of cell death called pyroptosis. Depending on external stimuli (bacterial, viral infections, cell damage, changes in ion concentration), various types of inflammasomes are activated. The possibilities of using caspase-1 inhibitors and other drugs in medicine were described.
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炎性小体:在疾病发病机制中的作用和治疗潜力
本文讨论了炎性小体的结构、发现历史及其作为治疗靶点的潜在用途。炎性小体是在各种外部和内部刺激(包括病毒和细菌感染)下形成的细胞质多蛋白复合物。炎症小体的主要产物是促炎细胞因子:白细胞介素-1- β (IL-1β)和白细胞介素-18 (IL-18)。这两种细胞因子都是通过活性caspase-1的蛋白水解裂解形成的。Caspase-1的激活导致一种特殊形式的细胞死亡,称为焦亡。根据外界刺激(细菌、病毒感染、细胞损伤、离子浓度变化),各种类型的炎性小体被激活。介绍了caspase-1抑制剂和其他药物在医学上应用的可能性。
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来源期刊
CiteScore
0.70
自引率
0.00%
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0
审稿时长
17 weeks
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