Statins Do Not Impair Whole-body Fat Oxidation During Moderate-intensity Exercise in Dyslipidemic Adults

Abstract

Lipid-lowering drugs are amongst the most commonly subsidized prescribed drugs world-wide, including Europe and the United States (USA). In 2016, atorvastatin and simvastatin were ranked in positions 1 and 7 in the USA [1]. In the same year, in Australia, atorvastatin and rosuvastatin were in positions 1 and 3, with the number of Australians per thousand taking the drug daily being 53 for atorvastatin and 34 for rosuvastatin [2]. Physiologically, these drugs inhibit liver enzyme HMGCoA reductase, blocking cholesterol synthesis. They are recognized as effective in the secondary prevention of cardiovascular disease and all-cause mortality [3]. However, it is now well established that a healthy diet and regular physical activity are valuable contributors to maintaining healthy blood lipids, with exercise improving cardiovascular fitness; reducing all-cause mortality and the risk of coronary heart and cardiovascular disease, stroke, type 2 diabetes mellitus Research Article Exercise Medicine Open Access eISSN: 2508-9056