Andreas Faissner , Bernhard Götz , Angret Joester , Angela Scholze
{"title":"The tenascin gene family—versatile glycoproteins implicated in neural pattern formation and regeneration","authors":"Andreas Faissner , Bernhard Götz , Angret Joester , Angela Scholze","doi":"10.1016/S1044-5781(06)80023-X","DOIUrl":null,"url":null,"abstract":"<div><p>The last years have shown that astro- and also oligodendroglia, in addition to supportive properties, may impose restrictions on the pathways of migrating neurons and of extending axonal projections. These inhibitory qualities of central nervous system glia may be important for neural pattern formation. Furthermore, inhibitory properties of glia could play an essential role in the failure of CNS regeneration. The present review discusses the tenascin glycoproteins, extracellular matrix components which belong to a growing family of structurally related genes. Some of these, in particular tenascin and janusin/restrictin, are expressed by glial lineages in the brain and exert both stimulatory and repulsive effects on CNS neurons <em>in vitro</em>.</p></div>","PeriodicalId":101155,"journal":{"name":"Seminars in Developmental Biology","volume":"6 2","pages":"Pages 139-148"},"PeriodicalIF":0.0000,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1044-5781(06)80023-X","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Developmental Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S104457810680023X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16
Abstract
The last years have shown that astro- and also oligodendroglia, in addition to supportive properties, may impose restrictions on the pathways of migrating neurons and of extending axonal projections. These inhibitory qualities of central nervous system glia may be important for neural pattern formation. Furthermore, inhibitory properties of glia could play an essential role in the failure of CNS regeneration. The present review discusses the tenascin glycoproteins, extracellular matrix components which belong to a growing family of structurally related genes. Some of these, in particular tenascin and janusin/restrictin, are expressed by glial lineages in the brain and exert both stimulatory and repulsive effects on CNS neurons in vitro.
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