D. Huang, Wei Liu, Zhaolong Huang, Yashun Chen, Jing Wang, Na Wu
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引用次数: 0
Abstract
Mathematical mass transfer model of racemic resolution for chiral compounds using HFSLM was presented in this study. Factors such as transportation resistance of boundary layers in strip phase inside the hollow fiber and in feed phase on the shell side of the hollow fiber module, diffusion resistance in the membrane solution and equilibrium constant of interfacial chemical reactions are considered in this mathematical model. The validity of the model is tested by resolution of D, L-phenylalanine with HFSLM using CuN2 as chiral carrier dissolved in a organic solvent (hexanol :decane, 1:1). Using experimental results, several parameters of the proposed model have been achieved by nonlinear fitting method.
本文建立了手性化合物外消旋体分离的数学传质模型。该数学模型考虑了中空纤维内部条相和中空纤维模块壳侧进料相边界层的输运阻力、膜溶液中的扩散阻力和界面化学反应的平衡常数等因素。在有机溶剂(己醇:癸烷，1:1)中，以CuN2为手性载体，用HFSLM分离D, l -苯丙氨酸，验证了模型的有效性。根据实验结果，采用非线性拟合方法得到了该模型的若干参数。
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