Genome editing: An essential technology for cancer treatment

Medicine in Omics Pub Date : 2022-06-01 DOI:10.1016/j.meomic.2022.100015

Muhammad Tufail

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引用次数: 3

Abstract

When genetic engineering was first developed in the 1970s, it opened new possibilities for genome editing. The life sciences have reaped numerous gains from gene-editing technology. The CRISPR/Cas9 system makes adding or removing sequence-specific amounts of DNA from the genome with ease achievable. CRISPR/Cas9 targeting efficiency improves, and concerted efforts reduce off-target effects. Cancer biology and oncology utilise CRISPR/Cas9 applications to do robust site-specific gene editing, making the technology valuable for research and therapeutic use. CRISPR/Cas9 is quickly evolving into several variations and uses. Helped by CRISPR-based techniques, scientists have developed a simple and inexpensive tool for developing powerful cancer therapies. CRISPR-based gene-editing technologies in oncology, gene editing for personalised medicine and overcoming resistance to cancer therapies, targeted therapies, optimisation of gene-editing technology and future cancer therapeutics are discussed in this review.

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基因组编辑:癌症治疗的关键技术

当基因工程在20世纪70年代首次发展时，它为基因组编辑开辟了新的可能性。生命科学已经从基因编辑技术中获益良多。CRISPR/Cas9系统可以轻松地从基因组中添加或删除特定序列数量的DNA。提高CRISPR/Cas9靶向效率，共同努力减少脱靶效应。癌症生物学和肿瘤学利用CRISPR/Cas9应用程序进行强大的位点特异性基因编辑，使该技术具有研究和治疗用途的价值。CRISPR/Cas9正在迅速演变成几种变体和用途。在基于crispr技术的帮助下，科学家们已经开发出一种简单而廉价的工具，用于开发强大的癌症治疗方法。本文综述了基于crispr的肿瘤基因编辑技术、个体化药物和克服癌症治疗耐药的基因编辑、靶向治疗、基因编辑技术的优化和未来癌症治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medicine in Omics

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