Evaluation of Dose Dependent Chemopreventive Effect of Diosmin on Induced Oral Squamous Cell Carcinoma

Menna-tallah Osman, Amany Taha, Nadia A. Radi, Eman AboHager
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Abstract

Purpose: This study aimed to evaluate the chemoprevention efficacy of diosmin on experimentally induced hamster buccal pouch (HBP) squamous cell carcinoma utilizing Ki 67 as a proliferative marker. Material and Methods : Seventy Syrian male hamsters were used as experimental animals, these hamsters were divided into five groups, Group I (negative control): 5 hamsters were left untreated. Group II (DMBA treated group): 20 hamsters were divided equally into two subgroups, painted with 0.5% DMBA where subgroup IIa: for 8 weeks while subgroup IIb: for 14 weeks. Group III: 5 hamsters were orally administrated diosmin 150 mg/kg for 14 weeks. Group IV: 20 hamsters were divided equally into two subgroups, treated with diosmin 100mg/kg and DMBA where subgroup IVa: for 8 weeks while subgroup IVb: for 14 weeks. Group V: 20 hamsters were divided equally into two subgroups, treated with diosmin 150mg/ kg and DMBA where subgroup Va: for 8 weeks while subgroup Vb: for 14 weeks. Results : Comparing all groups and subgroups revealed that the mean values have been arranged with the following descending pattern subgroup IIa, subgroup Va, subgroup IIb, subgroup Vb, subgroup IVb, subgroup IVa, group III and group I. ANOVA test revealed a statistically significant difference between groups. Conclusion : Diosmin 100mg/kg is considered a promising chemopreventive agent in preventing induced HBP squamous cell carcinoma.
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地奥司明对口腔鳞状细胞癌剂量依赖性化学预防作用的评价
目的:以Ki 67为增殖标志物,评价地奥米明对实验性诱导的仓鼠颊袋(HBP)鳞状细胞癌的化学预防作用。材料与方法:选取70只雄性叙利亚仓鼠作为实验动物,将其分为5组,1组(阴性对照):5只仓鼠未经处理。第二组(DMBA处理组):20只仓鼠平均分为两个亚组,分别用0.5% DMBA涂药,其中IIa亚组涂药8周,IIb亚组涂药14周。III组:5只仓鼠口服地臭虫胺150 mg/kg,连续14周。IV组:20只仓鼠平均分为2个亚组,分别给予地奥霉素100mg/kg和DMBA治疗,IVa亚组8周,IVb亚组14周。V组:20只仓鼠平均分为2个亚组,分别给予地奥霉素150mg/ kg和DMBA治疗,其中Va亚组8周,Vb亚组14周。结果:各组和亚组比较,均值按以下降序排列:亚组IIa、亚组Va、亚组IIb、亚组Vb、亚组IVb、亚组IVa、组III、组i。方差分析显示,组间差异有统计学意义。结论:100mg/kg地奥司明是一种很有前景的预防HBP鳞状细胞癌的化学制剂。
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