Enterobacter cloacae inhibits human rotavirus infectivity in vitro

Abstract

Rotavirus (RV), within the Reoviridae family, is a non-enveloped virus with 11 segments of double-stranded RNA and it is classified into 50 P types and 35 G on the basis of VP4 (protease-sensitive) and VP7 (glycoprotein) protein,6 respectively. RV represent the most important etiologic agents of viral gastroenteritis in infants and young children, as well as many young animals world wide.7 It is also the major viral agent of acute gastroenteritis in children<5 years of age, which may lead to death in severe cases.8 The primary rout of RV transmission is the fecal-oral route via person-to-person contact or swallowing of fecally contaminated water and food, with waterborne being one of the most important exposure pathways.9–11 Currently no efficient drug inhibit RV infections and vaccines remains the only effective and economical means to control and prevent RV infections.12