Experience with OK-432 in lymphatic vascular malformations in a hospital from northern Mexico

Jorge Alberto Cantú-Reyes, Erik Antonio Mier-Escurra, Joel Cázares-Rangel, J. R. D. Ita, Jan A Lammel-Lindemann, Luis Francisco Rendón-García, Boris José Chacón-López
{"title":"Experience with OK-432 in lymphatic vascular malformations in a hospital from northern Mexico","authors":"Jorge Alberto Cantú-Reyes, Erik Antonio Mier-Escurra, Joel Cázares-Rangel, J. R. D. Ita, Jan A Lammel-Lindemann, Luis Francisco Rendón-García, Boris José Chacón-López","doi":"10.24875/bmhime.m18000027","DOIUrl":null,"url":null,"abstract":"Background: Lymphatic vascular malformations (LVM) or formerly called lymphangiomas are congenital malformations present in about 1 out of 6,000 to 16,000 births. The most relevant classification system for lymphangioma management is based on the size of the cysts. Spontaneous resolution is uncommon; thus, expectant management is not recommended. The classic treatment is excisional surgery, but it can affect adjacent structures or have relapses, so, sclerosing substances like OK432 are being studied. The majority of the studies are in a small sample of patients and are from Japan; the largest studies in Mexico are focused on specific lesions (macrocystic) or a determined anatomical region. To date, there are no studies of the population of the north of Mexico. Methods: The experience with OK-432 was described through a retrospective, descriptive study in patients with LVM, from 2011 to 2016, in a reference hospital of northern Mexico. Results: A total of 26 patients with LVM were treated with OK-432. The majority of the lesions were macrocystic (69%), microcystic (19%) and mixed (12%). From the total number of patients, 11 fully healed, and 72% of the study population had > 50% reduction in lesion size with only two applications. There were no recurrences. Complications were reported in two patients who had skin hyperpigmentation. conclusions: OK-432 probed to be an effective treatment for LVM in a reference hospital in the north of Mexico.","PeriodicalId":100195,"journal":{"name":"Boletín Médico Del Hospital Infantil de México (English Edition)","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Boletín Médico Del Hospital Infantil de México (English Edition)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24875/bmhime.m18000027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Lymphatic vascular malformations (LVM) or formerly called lymphangiomas are congenital malformations present in about 1 out of 6,000 to 16,000 births. The most relevant classification system for lymphangioma management is based on the size of the cysts. Spontaneous resolution is uncommon; thus, expectant management is not recommended. The classic treatment is excisional surgery, but it can affect adjacent structures or have relapses, so, sclerosing substances like OK432 are being studied. The majority of the studies are in a small sample of patients and are from Japan; the largest studies in Mexico are focused on specific lesions (macrocystic) or a determined anatomical region. To date, there are no studies of the population of the north of Mexico. Methods: The experience with OK-432 was described through a retrospective, descriptive study in patients with LVM, from 2011 to 2016, in a reference hospital of northern Mexico. Results: A total of 26 patients with LVM were treated with OK-432. The majority of the lesions were macrocystic (69%), microcystic (19%) and mixed (12%). From the total number of patients, 11 fully healed, and 72% of the study population had > 50% reduction in lesion size with only two applications. There were no recurrences. Complications were reported in two patients who had skin hyperpigmentation. conclusions: OK-432 probed to be an effective treatment for LVM in a reference hospital in the north of Mexico.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在墨西哥北部医院淋巴血管畸形中使用OK-432的经验
背景:淋巴血管畸形(LVM)或以前称为淋巴管瘤是一种先天性畸形,大约6,000至16,000个新生儿中有1个。淋巴管瘤管理的最相关的分类系统是基于囊肿的大小。自发解决是不常见的;因此,不建议采用准管理。经典的治疗方法是切除手术,但它会影响邻近的结构或复发,因此,像OK432这样的硬化物质正在研究中。大多数研究都是来自日本的小样本患者;墨西哥最大的研究集中在特定病变(大囊性)或确定的解剖区域。到目前为止,还没有关于墨西哥北部人口的研究。方法:对墨西哥北部某参考医院2011 - 2016年LVM患者进行回顾性、描述性研究,总结OK-432治疗经验。结果:共有26例LVM患者接受了OK-432治疗。多数病变为大囊性(69%)、微囊性(19%)和混合性(12%)。从患者总数来看,11例完全愈合,72%的研究人群仅使用两次应用,病变大小缩小了50%以上。没有复发。报告了2例皮肤色素沉着的并发症。结论:在墨西哥北部的一家参考医院,OK-432被认为是治疗LVM的有效药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The impact of body mass index on blood pressure measured with a mercury sphygmomanometer in children and adolescents with type 1 diabetes mellitus Childhood rosacea Seroprevalence of Bordetella pertussis in pediatric healthcare workers at the Hospital Infantil de México Federico Gómez A mobile application for biliary atresia screening Validation of an instrument to measure the quality of life in children with oropharyngeal mucositis undergoing cancer treatment
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1