Recent Developments in Quorum Sensing-Based Suppression of Intestinal Pathogenic Bacteria

Abstract

Quorum sensing (QS) is a way for bacteria to communicate with each other. It works by making, releasing, and identifying AIs (autoinducers). It is critical for the growth of microorganisms and is a vital component of the immune system. In the intestinal environment, Salmonella Typhimurium, Vibrio cholera, Clostridium difficile, Escherichia coli and other intestinal pathogens infect the host body, affecting the normal immune metabolism process of the host body, resulting in acute gastroenteritis, dysentery and other diseases. Antibiotics can treat the concurrent infection caused by intestinal pathogens in the traditional treatment. Because of this, antibiotics should be used sparingly. Overuse of antibiotics can lead to the expansion of a wide range of antibiotic resistance in bacteria, which can then spread and evolve through genetic mutation. In recent years, more studies have shown that bacterial biofilm formation, virulence factor production, and drug resistance inhibition can be regulated by manipulating the QS system. Firstly, the working paths of several typical bacterial QS systems were summarized. The therapeutic strategies of QS for several common intestinal pathogens were reviewed to provide some references for developing new therapeutic schemes for intestinal diseases and related inhibitors of intestinal pathogens.