CLINICO-EPIDEMIOLOGICAL FEATURES OF PATIENTS WITH ENDOMETRIAL CARCINOMA IN CLINICAL ONCOLOGY DEPARTMENT IN AIN SHAMS UNIVERSITY HOSPITALS IN EGYPT

Abstract

: Background: Endometrial carcinoma (EC) is the most common gynaecological malignancy in high-income countries. Several studies have demonstrated the prognostic importance of different parameters including the histological subtypes, grade, stage, depth of myometrial invasion, lymphovascular space involvement, positive peritoneal cytology and cervical involvement. Aim of the Work: To analyse retrospectively epidemiological, clinicopathological features, treatment strategies and survival outcomes of patients diagnosed with EC. Patients and Methods: This is a retrospective study that included 65 patients diagnosed with EC attending the gastrointestinal and gynecological malignancies clinic at the Clinical Oncology Department, Ain Shams University, in the period from January 2017 to December 2020. Results: The mean age at diagnosis was 61 years, most of the patients 90.8% were postmenopausal and the mean BMI was 38.7 kg/m2. The 5-year overall survival (OS) was 83%, with a mean of 57.8 months, and the 5-year disease free survival was 79% with a mean of 49 months. Among the prognostic factors that were analyzed, only FIGO stage and depth of myometrial invasion showed statistically significant impact on survival. The 5-year OS was 100% for stage IA, 81% for stage IB, 88.9% for stage II, 83% for stage IIIA, 66.7% for stage IIIB and none of those with stage IIIC survived till the end of our study (p<0.001). The 5-year OS for those with myometrial invasion <50% was 100% while those with myometrial invasion ≥50% was 76% (p=0.025). Conclusion: We conclude that the FIGO stage and depth of myometrial invasion are the most significant prognostic factors and strong predictors of survival.