Viral strategies to modulate NKG2D-ligand expression in Human Cytomegalovirus infection

New horizons in translational medicine Pub Date : 2015-09-01 DOI:10.1016/j.nhtm.2015.11.002

Hugh Reyburn , Gloria Esteso , Omodele Ashiru , Mar Vales-Gomez

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引用次数: 3

Abstract

Human cytomegalovirus is a paradigm for studies of viral strategies of immune evasion. In particular, the virus has developed multiple mechanisms for evasion of immune surveillance by lymphocytes expressing the activating receptor NKG2D. The human genome encodes several ligands able to bind NKG2D and in this article we review and discuss what is known about the various viral proteins and micro RNAs that act to minimise the recognition of the infected cell by modulation of the expression and trafficking of the different NKG2D ligand molecules.

Focal points

•
The activating receptor NKG2D is important in the immune response to HCMV.
•
HCMV has developed multiple strategies to evade immunosurveillance by cytotoxic lymphocytes expressing NKG2D.
•
A better understanding of immune evasion by HCMV will likely be relevant for the development of better vaccination strategies.

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人巨细胞病毒感染中调节nkg2d配体表达的病毒策略

人类巨细胞病毒是研究病毒免疫逃避策略的一个范例。特别是，该病毒已经发展出多种机制，通过表达激活受体NKG2D的淋巴细胞逃避免疫监视。人类基因组编码几种能够结合NKG2D的配体，在本文中，我们回顾和讨论了各种病毒蛋白和微rna的已知情况，这些病毒蛋白和微rna通过调节不同NKG2D配体分子的表达和运输来最大限度地减少对感染细胞的识别。•激活受体NKG2D在HCMV的免疫反应中很重要。•HCMV已经发展出多种策略来逃避表达NKG2D的细胞毒性淋巴细胞的免疫监视。•更好地了解HCMV的免疫逃避可能与开发更好的疫苗接种策略有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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New horizons in translational medicine

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