CMOS image sensor for measurement of glucose in mouse plasma

Abstract

Complementary metal oxide semiconductor (CMOS) technology has an emerging filed in molecular diagnostics and other biological applications. The present study demonstrated that CMOS image sensor based glucose monitoring in mouse plasma by simple photon number changes. The photon number varied in the basis of color differences of oxidized glucose in polydimethylsiloxane (PDMS) chip. The high concentration of glucose produces more color and was allowed to pass less number of photons; the photon numbers are gradually increased with less concentration of glucose. Number of photons are depends on the density of color in mouse glucose. The photons are captured and converted as a digital numbers. The UV-spectral study helps to confirmed that the CMOS image sensor is a precise detection system for glucose measurement by point-of-care approach.