THE IDENTIFICATION AND STUDY OF HERBAL MEDICINE (JAMU) FRAGMENTATION PATTERNS CONFIRMED ACETAMINOPHEN BY USING LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY (LCMS)

Muhammad Taupik, Endah Nurrohwinta Djuwarno, M.Sc Mohammad Adam Mustapa, Muhamad Handoyo Sahumena
{"title":"THE IDENTIFICATION AND STUDY OF HERBAL MEDICINE (JAMU) FRAGMENTATION PATTERNS CONFIRMED ACETAMINOPHEN BY USING LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY (LCMS)","authors":"Muhammad Taupik, Endah Nurrohwinta Djuwarno, M.Sc Mohammad Adam Mustapa, Muhamad Handoyo Sahumena","doi":"10.55047/comorbid.v1i1.38","DOIUrl":null,"url":null,"abstract":"\nIn the last twenty years, many of jamu or herbal medicine were adulterated with chemical drugs. One of the chemical drugs that is commonly added to herbal medicine is acetaminophen. Acetaminophen is generally considered as an analgesic-antipyretic drug. The sample of this study consisted of 6 samples of jamu or herbal medicine with different brands. Qualitative analysis was conducted by TLC method using the mobile phase n-hexane: ethyl acetate (1:1), it was obtained three positive samples containing acetaminophen, namely sample D, E, and F. The three positive samples containing acetaminophen were calculated using the LCMS method. Quantitative analysis was conducted with LCMS using a reversed-phase with a mobile phase of acetonitrile: water (15%>: 85%> v/v) at a flow rate of 0.2 mL/min and an injection volume of 5 gL, it was obtained the levels of acetaminophen in sample D as much as 0.16 g/2 g of sample, in sample E of 0.63 g/7 g of sample, and in sample F of 0.56 g/7 g of sample. Although the content of acetaminophen in herbal medicine is relatively small, but according to the Regulation of the Minister of Health of Indonesia No. 007 of 2012, traditional medicine or herbal medicine should not contain synthetic chemicals. \n","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":"10 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55047/comorbid.v1i1.38","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

In the last twenty years, many of jamu or herbal medicine were adulterated with chemical drugs. One of the chemical drugs that is commonly added to herbal medicine is acetaminophen. Acetaminophen is generally considered as an analgesic-antipyretic drug. The sample of this study consisted of 6 samples of jamu or herbal medicine with different brands. Qualitative analysis was conducted by TLC method using the mobile phase n-hexane: ethyl acetate (1:1), it was obtained three positive samples containing acetaminophen, namely sample D, E, and F. The three positive samples containing acetaminophen were calculated using the LCMS method. Quantitative analysis was conducted with LCMS using a reversed-phase with a mobile phase of acetonitrile: water (15%>: 85%> v/v) at a flow rate of 0.2 mL/min and an injection volume of 5 gL, it was obtained the levels of acetaminophen in sample D as much as 0.16 g/2 g of sample, in sample E of 0.63 g/7 g of sample, and in sample F of 0.56 g/7 g of sample. Although the content of acetaminophen in herbal medicine is relatively small, but according to the Regulation of the Minister of Health of Indonesia No. 007 of 2012, traditional medicine or herbal medicine should not contain synthetic chemicals.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
用液相色谱-质谱法(lcms)鉴定对乙酰氨基酚(acetaminophen)的破碎型
在过去的二十年里,许多查谟或草药都掺入了化学药物。通常添加到草药中的化学药物之一是对乙酰氨基酚。对乙酰氨基酚通常被认为是一种镇痛解热药物。本研究的样本包括6个不同品牌的jamu或草药样品。采用流动相正己烷:乙酸乙酯(1:1)的薄层色谱法进行定性分析,得到3个含对乙酰氨基酚的阳性样品,分别为样品D、E、f。3个含对乙酰氨基酚的阳性样品采用LCMS法计算。采用LCMS进行定量分析,流动相为乙腈:水(15%>:85%> v/v),流速为0.2 mL/min,进样量为5 gL,样品D中对乙酰氨基酚含量为0.16 g/2 g,样品E中为0.63 g/7 g,样品F中为0.56 g/7 g。虽然草药中对乙酰氨基酚的含量相对较少,但根据印度尼西亚卫生部2012年第007号条例,传统药物或草药不应含有合成化学品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
EFFORTS TO INCREASE PREGNANT WOMEN'S KNOWLEDGE ABOUT HIGH-RISK PREGNANCY WITH HEALTH EDUCATION DESCRIPTION OF FALL RISK FACTORS ON FALLING INCIDENTS AMONG THE ELDERLY IN THE WORKING AREA OF KRUENG BARONA JAYA HEALTH CENTER DESCRIPTION OF THE UNDERSTANDING AND CONCERN OF CHILDREN WITH SPECIAL NEEDS FOR EAR HYGIENE, EAR INFECTION AND HEARING HEALTH AT GOVERNMENT SPECIAL SCHOOL II BANJARMASIN LITERATURE REVIEW: PREGNANT WOMEN NUTRITION DURING A PANDEMIC LUNG BULLAE DUE TO SEPTIC PULMONARY EMBOLISM IN A 4-YEAR-OLD CHILD: A CASE REPORT
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1