Lipid Peroxidation in the Pre-Reactive Period of Cold Injury

V. Nikolaev, S. Sofronova, E. Rumyantsev, Z. Alekseeva, N. Chirikova, N. A. Sleptsova, S. A. Fedorova
{"title":"Lipid Peroxidation in the Pre-Reactive Period of Cold Injury","authors":"V. Nikolaev, S. Sofronova, E. Rumyantsev, Z. Alekseeva, N. Chirikova, N. A. Sleptsova, S. A. Fedorova","doi":"10.29413/abs.2020-5.2.1","DOIUrl":null,"url":null,"abstract":"Pathological processes in the pre-reactive period of cold injury have not been studied. The purpose of this study is to assess the morphological and biochemical parameters of blood in the body of patients in the pre-reactive period of cold injury. Material and methods. We examined patients with cold injury in the pre-reactive period. Determined: diene conjugates, malonic dialdehyde, the total content of low molecular weight antioxidants, superoxide dismutase activity, catalase, glutathione peroxidase, glutathione reductase, using a SPECORD 40 spectrophotometer. The serum biochemical parameters in the serum were determined by biochemical automator analysis. Statistical processing of the data was performed using IBM SPSS Statistics 19. Results and discussion. Features of the biochemical profile of blood in the pre-reactive period of cold injury in the human body are an increase in concentration of glucose and triacylglycerides in blood, an increase in transaminase activity, as aresult of inflammatory and destructive processes, a decrease in the cholesterol concentration in the blood of patients. At the same time, the pre-reactive period of cold injury is characterized by an increase in monocytes compared with the control, which, in combination with hypoxia, leads to an intensification of lipid peroxidation processes. In addition, the antioxidant protection in the pre-reactive period in the body of patients increased slightly. Conclusion. According to the results of our research, already at the stage of the pre-reactive period of cold injury there is a significant intensification of free radical lipid oxidation processes.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29413/abs.2020-5.2.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Pathological processes in the pre-reactive period of cold injury have not been studied. The purpose of this study is to assess the morphological and biochemical parameters of blood in the body of patients in the pre-reactive period of cold injury. Material and methods. We examined patients with cold injury in the pre-reactive period. Determined: diene conjugates, malonic dialdehyde, the total content of low molecular weight antioxidants, superoxide dismutase activity, catalase, glutathione peroxidase, glutathione reductase, using a SPECORD 40 spectrophotometer. The serum biochemical parameters in the serum were determined by biochemical automator analysis. Statistical processing of the data was performed using IBM SPSS Statistics 19. Results and discussion. Features of the biochemical profile of blood in the pre-reactive period of cold injury in the human body are an increase in concentration of glucose and triacylglycerides in blood, an increase in transaminase activity, as aresult of inflammatory and destructive processes, a decrease in the cholesterol concentration in the blood of patients. At the same time, the pre-reactive period of cold injury is characterized by an increase in monocytes compared with the control, which, in combination with hypoxia, leads to an intensification of lipid peroxidation processes. In addition, the antioxidant protection in the pre-reactive period in the body of patients increased slightly. Conclusion. According to the results of our research, already at the stage of the pre-reactive period of cold injury there is a significant intensification of free radical lipid oxidation processes.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
冷损伤前反应期的脂质过氧化
冷损伤前反应期的病理过程尚未研究。本研究的目的是评估冷损伤前反应期患者体内血液的形态学和生化参数。材料和方法。我们检查了反应前期的冷损伤患者。测定:二烯偶联物,丙二醛,低分子量抗氧化剂总含量,超氧化物歧化酶活性,过氧化氢酶,谷胱甘肽过氧化物酶,谷胱甘肽还原酶,使用SPECORD 40分光光度计。采用生化自动仪检测血清生化指标。采用IBM SPSS Statistics 19对数据进行统计处理。结果和讨论。在人体冷损伤反应前,血液生化特征是血液中葡萄糖和甘油三酯浓度升高,转氨酶活性升高,这是炎症和破坏过程的结果,患者血液中胆固醇浓度降低。与此同时,与对照组相比,冷损伤前反应期的特点是单核细胞增加,这与缺氧相结合,导致脂质过氧化过程加剧。此外,患者体内反应前期的抗氧化保护作用略有增加。结论。根据我们的研究结果,在冷损伤的反应前阶段,自由基脂质氧化过程已经显著增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Involvement of the ERK MAPK Cascade in the Formation of Adhesions in the Abdominal Cavity Method for Surgical Treatment of Hammer Deformity of the Second Toe Using Combined Osteosynthesis in Trauma Practice in the Treatment of Diaphyseal Forearm Injuries Differential Reorganization of Structural Elements of the Iridociliary and Perenticular Zones in the Hydrodynamic Blocks Formation Commitment of Parents and Doctors of Irkutsk City to Vaccination against Tick-Borne Encephalitis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1