Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.29
S. Leonova, V. Monastyrev, N. Ponomarenko
{"title":"Using a New Method for Preparing an Autograft for Anterior Cruciate Ligament Plasty","authors":"S. Leonova, V. Monastyrev, N. Ponomarenko","doi":"10.29413/abs.2020-5.6.29","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.29","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89765180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.31
S. Leonova, I. Usoltsev, M. Kosareva
{"title":"Method for Surgical Treatment of Hammer Deformity of the Second Toe","authors":"S. Leonova, I. Usoltsev, M. Kosareva","doi":"10.29413/abs.2020-5.6.31","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.31","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74896712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.33
I. Shurygina, M. Shurygin, L. Rodionova, E. Chepurnykh, N. Ayushinova
{"title":"Involvement of the ERK MAPK Cascade in the Formation of Adhesions in the Abdominal Cavity","authors":"I. Shurygina, M. Shurygin, L. Rodionova, E. Chepurnykh, N. Ayushinova","doi":"10.29413/abs.2020-5.6.33","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.33","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73590487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Injuries and degenerative changes of tendons are common damages of the musculoskeletal system. Due to its hypovascular character the tendon has a limited natural ability to recover. For typical surgical treatment, the tendon integrity is restored, but in most cases, there occurs formation of the connective tissue scar resulting in structural and mechanical functionality disruption. The insufficient effectiveness of traditional therapy methods requires the search for alternative ways to restore damaged tendon tissues. This article discusses new effective methods for improving the treatment that base on the use of cellular technologies among which one of the main directions is mesenchymal stem cell application. Due to mesenchymal stem cells, there is a shift from pro-fibrotic and pro-inflammatory reactions of cells to pro-regenerative ones. Stem cells being multipotent and having among other things tenogenic potential are considered a promising material for repairing damaged tendons. The article also describes the sources of progenitor tendon cells including the tendon bundles and pericytes the main markers of which are Scx and Mkx that are proteins of the transcription factor superfamily, and Tnmd that is transmembrane glycoprotein.The growth factors that not only enhance the proliferative activity of mesenchymal stem cells but also promote in vitro tenogenic genes expression as well as the collagen Itype production what is necessary for tendon formation are considered. Along with growth factors, the morphogenetic protein BMP14 is presented, this protein increases themesenchymal stem cell proliferation and contributes directed tenogenic differentiation of these cells, suppressing their adipogenic and chondrogenic potentials.In recent years, mesenchymal stem cells have been used both separately and in combination with various growth factors and different three-dimensional structures providing the interaction with all of the cell types.The issues of the latest 3D-bioprinting technology allowing to make tissue-like structures for replacement damaged tissues and organs are discussed. 3D-bioprinting technology is known to allow acting exact spatio-temporal control of the distribution of cells, growth factors, small molecules, drugs and biologically active substances.
{"title":"Cellular Technologies in Traumatology: from Cells to Tissue Engineering","authors":"N. Dremina, I. Trukhan, I. Shurygina","doi":"10.29413/abs.2020-5.6.8","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.8","url":null,"abstract":"Injuries and degenerative changes of tendons are common damages of the musculoskeletal system. Due to its hypovascular character the tendon has a limited natural ability to recover. For typical surgical treatment, the tendon integrity is restored, but in most cases, there occurs formation of the connective tissue scar resulting in structural and mechanical functionality disruption. The insufficient effectiveness of traditional therapy methods requires the search for alternative ways to restore damaged tendon tissues. This article discusses new effective methods for improving the treatment that base on the use of cellular technologies among which one of the main directions is mesenchymal stem cell application. Due to mesenchymal stem cells, there is a shift from pro-fibrotic and pro-inflammatory reactions of cells to pro-regenerative ones. Stem cells being multipotent and having among other things tenogenic potential are considered a promising material for repairing damaged tendons. The article also describes the sources of progenitor tendon cells including the tendon bundles and pericytes the main markers of which are Scx and Mkx that are proteins of the transcription factor superfamily, and Tnmd that is transmembrane glycoprotein.The growth factors that not only enhance the proliferative activity of mesenchymal stem cells but also promote in vitro tenogenic genes expression as well as the collagen Itype production what is necessary for tendon formation are considered. Along with growth factors, the morphogenetic protein BMP14 is presented, this protein increases themesenchymal stem cell proliferation and contributes directed tenogenic differentiation of these cells, suppressing their adipogenic and chondrogenic potentials.In recent years, mesenchymal stem cells have been used both separately and in combination with various growth factors and different three-dimensional structures providing the interaction with all of the cell types.The issues of the latest 3D-bioprinting technology allowing to make tissue-like structures for replacement damaged tissues and organs are discussed. 3D-bioprinting technology is known to allow acting exact spatio-temporal control of the distribution of cells, growth factors, small molecules, drugs and biologically active substances. ","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83853478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.38
I. Kurganskiy
Background. The development of new methods for delivering biologically active substances to the surgical site is a promising area of modern surgery. One of the biologically active substances used to stimulate regeneration is the vascular endothelial growth factor (VEGF). The search for ways to gradually and over a long period of time deliver VEGF to the surgical site is a promising area of research. Aim. To develop a method for delivering VEGF to the surgical site and to assess its elimination in the early postopera-tive period. Materials and methods. The study included 78 male Wistar rats at the age of 10 months. All animals underwent reconstructive surgery on the trachea, the animals were divided into 3 groups: group 1 – without a medicinal film, group 2 – with a medicinal film of prolonged action, group 3 – with a medicinal film of prolonged action containing VEGF. Blood sampling was carried out on days 1, 3, and 21 of the study, using the method of enzyme-linked immuno- sorbent assay to determine the level of VEGF in blood plasma, the unit of measurement was pg/ml. Results. A long-acting medicinal film containing VEGF has been developed. It was revealed that the use of a medicinal film containing VEGF significantly increases the VEGF index in blood plasma by 26 times starting from the first day of the study and remained high throughout the study. Conclusion. The results obtained indicate the effectiveness of the developed medicinal film of prolonged action. Elimination of VEGF starts from the first day of the study and lasts up to 21 days. High VEGF indices, according to the authors, are associated with the exogenous introduction of VEGF into the animal organism in the form of a prolonged-action film and the induction of endogenous VEGF in rats.
{"title":"A Method of Manufacturing a Long-Acting Medicinal Film Containing VEGF","authors":"I. Kurganskiy","doi":"10.29413/abs.2020-5.6.38","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.38","url":null,"abstract":"Background. The development of new methods for delivering biologically active substances to the surgical site is a promising area of modern surgery. One of the biologically active substances used to stimulate regeneration is the vascular endothelial growth factor (VEGF). The search for ways to gradually and over a long period of time deliver VEGF to the surgical site is a promising area of research. Aim. To develop a method for delivering VEGF to the surgical site and to assess its elimination in the early postopera-tive period. Materials and methods. The study included 78 male Wistar rats at the age of 10 months. All animals underwent reconstructive surgery on the trachea, the animals were divided into 3 groups: group 1 – without a medicinal film, group 2 – with a medicinal film of prolonged action, group 3 – with a medicinal film of prolonged action containing VEGF. Blood sampling was carried out on days 1, 3, and 21 of the study, using the method of enzyme-linked immuno- sorbent assay to determine the level of VEGF in blood plasma, the unit of measurement was pg/ml. Results. A long-acting medicinal film containing VEGF has been developed. It was revealed that the use of a medicinal film containing VEGF significantly increases the VEGF index in blood plasma by 26 times starting from the first day of the study and remained high throughout the study. Conclusion. The results obtained indicate the effectiveness of the developed medicinal film of prolonged action. Elimination of VEGF starts from the first day of the study and lasts up to 21 days. High VEGF indices, according to the authors, are associated with the exogenous introduction of VEGF into the animal organism in the form of a prolonged-action film and the induction of endogenous VEGF in rats.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"2017 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87439988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.23
N. Ponomarenko, V. Monastyrev, I. Kuklin, D. V. Menshova
{"title":"Arthroscopically Assisted Transposition of the Latissimus Dorsi in the Treatment of Patients with Massive Ruptures of the Rotator Cuff (Clinical Observation)","authors":"N. Ponomarenko, V. Monastyrev, I. Kuklin, D. V. Menshova","doi":"10.29413/abs.2020-5.6.23","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.23","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"270 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82797982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.34
O. A. Goldberg, A. Zhivotenko, L. G. Samoilova, V. Sorokovikov, I. Shurygina
{"title":"Change of the Shape of the Dural Sac in the Laminectomy Model at Different Stages of the Reparation in the Experiment","authors":"O. A. Goldberg, A. Zhivotenko, L. G. Samoilova, V. Sorokovikov, I. Shurygina","doi":"10.29413/abs.2020-5.6.34","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.34","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79094168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.28
M. Puseva, Ch. Z. Butaev, A. Rudakov
The article presents the experience of surgical treatment of a rare pathology of the upper limb – the pseudarthrosis of the middle third of the radial shaft with a bone defect in combination with the pseudarthrosis of the middle and lower third of the shaft of the ulna of the forearm. Determination of reasonable and well-considered treatment tactics is of great importance in the treatment of patients aimed at restoring the anatomy and function of the injured upper limb. A feature of this case is the formation of several false joints at different levels of the forearm bones, the presence of a bone defect of 2.5 cm, which required its replacement with an autograft, and a previously performed surgical in tervention using transosseous osteosynthesis. The applied tactics of surgical treatment consisted of several stages: bone osteosynthesis of the ulna with opening of the medullary canals of the ulna; replacement of a bone defect in the area of the pseudarthrosis of the radius with an autograft from the iliac crest using combined stress osteosynthesis in com - bination with transosseous osteosynthesis. The results of surgical treatment of false joints and bone defects depend on the correct treatment tactics, according to the indications, and the correct implementation of the selected treatment tactics. The surgical tactics of treatment used in this clinical situation made it possible to create conditions for the fu sion of fragments of the radius and ulna bones, as well as to replace the defect of the radius, as a result of which the anatomy and function of the damaged segment were successfully restored.
{"title":"Using Combined Osteosynthesis in Trauma Practice in the Treatment of Diaphyseal Forearm Injuries","authors":"M. Puseva, Ch. Z. Butaev, A. Rudakov","doi":"10.29413/abs.2020-5.6.28","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.28","url":null,"abstract":"The article presents the experience of surgical treatment of a rare pathology of the upper limb – the pseudarthrosis of the middle third of the radial shaft with a bone defect in combination with the pseudarthrosis of the middle and lower third of the shaft of the ulna of the forearm. Determination of reasonable and well-considered treatment tactics is of great importance in the treatment of patients aimed at restoring the anatomy and function of the injured upper limb. A feature of this case is the formation of several false joints at different levels of the forearm bones, the presence of a bone defect of 2.5 cm, which required its replacement with an autograft, and a previously performed surgical in tervention using transosseous osteosynthesis. The applied tactics of surgical treatment consisted of several stages: bone osteosynthesis of the ulna with opening of the medullary canals of the ulna; replacement of a bone defect in the area of the pseudarthrosis of the radius with an autograft from the iliac crest using combined stress osteosynthesis in com - bination with transosseous osteosynthesis. The results of surgical treatment of false joints and bone defects depend on the correct treatment tactics, according to the indications, and the correct implementation of the selected treatment tactics. The surgical tactics of treatment used in this clinical situation made it possible to create conditions for the fu sion of fragments of the radius and ulna bones, as well as to replace the defect of the radius, as a result of which the anatomy and function of the damaged segment were successfully restored.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75237411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modern Understanding of the Gut Microbiotа in Patients with Diabetes Mellitus","authors":"E. Chugunova, M. Darenskaya","doi":"10.29413/abs.2020-5.6.6","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.6","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83833302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.13
L. Rodionova, L. G. Samoilova, V. Sorokovikov
Parathyroid hormone receptors PTH1R and PTH2R are poorly studied in the pathology of the vertebral column and may be involved in both ectopic ossification of the vertebral ligaments and fibrous growth of the extracellular matrix, as well as in other unknown processes occurring in the pathological focus. ActA BiomedicA ScientificA, 2020, Vol. 5, N 6 east Siberian Biomedical Journal 114 Morphology, physiology and pathophysiology Aim. To study the expression of genes encoding parathyroid hormone receptors in intraoperative Ligamentum flavum samples of patients with stenosis of the spinal canal and the lumbar dural sac of the spine and to assess the correlation with the expression of other genes active in connective tissue in conditions of developing pathology. Materials and methods. Studies of the Ligamentum flavum were performed in 33 patients (17 women, 16 men) with stenotic processes of the spinal canal and dural sac of the lumbar spine. RNA was isolated from the biopsies using Qiagen reagents (Germany). Then reverse transcription was performed. cDNA was used for setting up a polymerase chain reaction (Promega Reagents, USA) using a CFX96 thermal cycler (Biorad, USA) with specially selected specific primers. Results. The expression of genes encoding parathyroid hormone receptors PTH1R and PTH2R was detected and evaluated for the first time in intraoperative Ligamentum flavum samples of patients with spinal canal and dural sac stenosis, and their relationship with the activity of genes encoding estradiol receptors (ESR1 and ESR2) and FGFR3 was revealed. For the first time, common features of PTH1R and PTH2R gene expression, as well as their differences, were revealed. It is proved that the intensity of expression of parathyroid hormone receptors in intraoperative Ligamentum flavum biopsies does not depend on age, gender, or the presence of bone and cartilage nodes according to MRI results. The interdependence of differential changes in the expression of genes of the receptor apparatus involved in the metabolism of Ligamentum flavum tissues was revealed.
甲状旁腺激素受体PTH1R和PTH2R在脊柱病理中研究较少，可能参与椎韧带异位骨化和细胞外基质的纤维生长，以及病理病灶中发生的其他未知过程。生物医学学报，2020,Vol. 5, N . 6东西伯利亚生物医学杂志114形态学、生理学和病理生理学目的:研究椎管狭窄及腰椎硬膜囊患者术中黄韧带样本中甲状旁腺激素受体编码基因的表达情况，并探讨其与结缔组织中其他活性基因在病理发展状态下表达的相关性。材料和方法。我们对33例腰椎管和硬脊膜囊狭窄的患者(17名女性，16名男性)进行了黄韧带的研究。使用Qiagen试剂(德国)从活检中分离RNA。然后进行逆转录。cDNA用CFX96热循环器(Biorad，美国)建立聚合酶链反应(Promega试剂，美国)，特别选择特异性引物。结果。首次在椎管及硬膜囊狭窄患者术中黄韧带样本中检测并评价甲状旁腺激素受体PTH1R和PTH2R编码基因的表达，并揭示其与雌二醇受体(ESR1和ESR2)和FGFR3编码基因活性的关系。首次揭示了PTH1R和PTH2R基因表达的共同特征以及它们之间的差异。MRI结果证明术中黄韧带活检中甲状旁腺激素受体的表达强度与年龄、性别、骨和软骨淋巴结的存在无关。揭示了参与黄韧带组织代谢的受体器官基因表达差异变化的相互依赖性。
{"title":"Activity of Parathyroid Hormone Receptor Genes in Ligamentum Flavum Biopsies of Patients with Spinal Canal and Dural Sac Stenosis at the Lumbar Level","authors":"L. Rodionova, L. G. Samoilova, V. Sorokovikov","doi":"10.29413/abs.2020-5.6.13","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.13","url":null,"abstract":"Parathyroid hormone receptors PTH1R and PTH2R are poorly studied in the pathology of the vertebral column and may be involved in both ectopic ossification of the vertebral ligaments and fibrous growth of the extracellular matrix, as well as in other unknown processes occurring in the pathological focus. ActA BiomedicA ScientificA, 2020, Vol. 5, N 6 east Siberian Biomedical Journal 114 Morphology, physiology and pathophysiology Aim. To study the expression of genes encoding parathyroid hormone receptors in intraoperative Ligamentum flavum samples of patients with stenosis of the spinal canal and the lumbar dural sac of the spine and to assess the correlation with the expression of other genes active in connective tissue in conditions of developing pathology. Materials and methods. Studies of the Ligamentum flavum were performed in 33 patients (17 women, 16 men) with stenotic processes of the spinal canal and dural sac of the lumbar spine. RNA was isolated from the biopsies using Qiagen reagents (Germany). Then reverse transcription was performed. cDNA was used for setting up a polymerase chain reaction (Promega Reagents, USA) using a CFX96 thermal cycler (Biorad, USA) with specially selected specific primers. Results. The expression of genes encoding parathyroid hormone receptors PTH1R and PTH2R was detected and evaluated for the first time in intraoperative Ligamentum flavum samples of patients with spinal canal and dural sac stenosis, and their relationship with the activity of genes encoding estradiol receptors (ESR1 and ESR2) and FGFR3 was revealed. For the first time, common features of PTH1R and PTH2R gene expression, as well as their differences, were revealed. It is proved that the intensity of expression of parathyroid hormone receptors in intraoperative Ligamentum flavum biopsies does not depend on age, gender, or the presence of bone and cartilage nodes according to MRI results. The interdependence of differential changes in the expression of genes of the receptor apparatus involved in the metabolism of Ligamentum flavum tissues was revealed.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"9 38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83263247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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