An analytical review on the quantitative techniques for estimation of cilostazol in pharmaceutical preparations and biological samples

IF 3.6 3区化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2021-01-01 DOI:10.1515/revac-2021-0128

Afnaan Afreen, C. Nalini

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Abstract

Abstract Cilostazol (CLZ) is a quinolinone derivative possessing anti platelet and vasodilating properties and it is used in the treatment of intermittent claudication. It operates by inhibiting the cyclic guanosine monophosphate (cGMP) dependent phosphodiesterase III which leads to availability of cyclic adenosine monophosphate (cAMP) in blood vessels and platelets owing to vasodilation and reduced calcium-induced contractions. This article illustrates the various reported quantitative methods which can be used to determine cilostazol and its metabolites either alone or in combination forms in pharmaceutical preparation or biological matrices like plasma, serum, and urine. The review covers analytical methods like ultraviolet spectroscopy, fluorescence spectroscopy, electrometric methods, nuclear magnetic resonance spectroscopy, high performance liquid chromatography, high performance thin layer chromatography, ultra-high performance liquid chromatography, and tandem mass spectroscopy from the year 1985 to 2019 with a brief explanation on every analytical method. Among the methods, it was found that most researchers opted for UV and HPLC analytical methods for the estimation of cilostazol.

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药物制剂和生物样品中西洛他唑含量测定技术的分析综述

西洛他唑(Cilostazol, CLZ)是一种喹诺啉酮类衍生物，具有抗血小板和血管舒张的特性，用于治疗间歇性跛行。它通过抑制环单磷酸鸟苷(cGMP)依赖的磷酸二酯酶III，导致血管和血小板中环单磷酸腺苷(cAMP)的可用性，这是由于血管舒张和钙诱导的收缩减少。本文阐述了各种报道的定量方法，这些方法可用于测定西洛他唑及其代谢物，无论是单独的还是在药物制剂或生物基质(如血浆、血清和尿液)中的联合形式。回顾了1985年至2019年的分析方法，如紫外光谱法、荧光光谱法、电计量法、核磁共振光谱法、高效液相色谱法、高效薄层色谱法、超高液相色谱法、串联质谱法等，并对每种分析方法进行了简要说明。在这些方法中，大多数研究者选择紫外分光光度法和高效液相色谱法进行西洛他唑的测定。

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来源期刊

Reviews in Analytical Chemistry 化学-分析化学

CiteScore

7.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.