Benefits of Oral Contraceptive Pill Pretreatment in Endometriosis for IVF/ICSI-ET: A Retrospective Cohort Study

S. Chakrabartty, Hanwang Zhang, Xiyuan Dong, M. O. Alfred
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Abstract

Pretreatment with oral contraceptive pills (OCP) has been widely applied in IVF/ICSI –ET treatment. However, it remains unclear whether OCP influences pregnancy rate of fresh cycle and subsequent cumulative pregnancy rate in patients with endometriosis. In this retrospective study, a total of 512 first attempt IVF/ICSI cycles of patients with endometriosis were included and divided into two groups: the study group included 216 cycles of patients undergoing pretreatment with OCP before pituitary suppression and ovarian stimulation, while 296 cycles of patients without pretreatment were considered as control. The ovarian stimulation performance and pregnancy results were compared between the two groups. Patients with OCP pretreatment required shorter duration, a lower dosage of gonadotropins, but obtained higher E2 level and more retrieved oocytes. Patients in the two groups obtained comparable fertilization rate, cleavage rate, but the number and rate of day 3 high-quality embryos were higher in OCP-pretreated patients. No differences were found in IVF/ICSI-ET outcomes, in terms of implantation rate, clinical pregnancy rates, live birth pregnancy rate, and cumulative pregnancy rate. In addition, despite the lack of statistical significance, a trend toward higher clinical pregnancy rate in a fresh cycle and cumulative pregnancy rate was found in OCP pretreated patients. It should be recommended that patients with endometriosis take OCP pretreatment before ovarian stimulation, since it offers advantages of lower cost and higher embryo-quality, and does not negatively influence pregnancy rates.Chakrabartty et al., International Current Pharmaceutical Journal, July 2017, 6(8): 44-48http://www.icpjonline.com/documents/Vol6Issue8/01.pdf
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口服避孕药预处理IVF/ICSI-ET子宫内膜异位症的益处:一项回顾性队列研究
口服避孕药预处理(OCP)在IVF/ICSI -ET治疗中应用广泛。然而,OCP是否影响子宫内膜异位症患者新鲜周期妊娠率和随后的累积妊娠率尚不清楚。本回顾性研究共纳入子宫内膜异位症患者首次尝试IVF/ICSI的512个周期,并分为两组:研究组在垂体抑制和卵巢刺激前进行OCP预处理的患者216个周期,未进行预处理的患者296个周期作为对照组。比较两组患者卵巢刺激效果及妊娠结果。OCP预处理时间较短,促性腺激素用量较低,但E2水平较高,回收卵母细胞较多。两组患者受精率、卵裂率相当,但ocp预处理患者第3天高质量胚胎的数量和比例更高。IVF/ICSI-ET在着床率、临床妊娠率、活产妊娠率和累计妊娠率方面均无差异。此外,OCP预处理组临床新周期妊娠率和累计妊娠率均有较高的趋势,但差异无统计学意义。建议子宫内膜异位症患者在卵巢刺激前进行OCP预处理,成本较低,胚胎质量较高,且不会对妊娠率产生负面影响。Chakrabartty等,国际药学杂志,2017,6(8):44-48http://www.icpjonline.com/documents/Vol6Issue8/01.pdf
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