Urinary excretion kinetics for evaluation of drug absorption. III. Method for calculation of absorption rate and application to tetracycline absorption in humans.
{"title":"Urinary excretion kinetics for evaluation of drug absorption. III. Method for calculation of absorption rate and application to tetracycline absorption in humans.","authors":"E. Nelson","doi":"10.1002/JPS.3030490709","DOIUrl":null,"url":null,"abstract":"A method was developed to calculate drug absorption rate from urinary excretion rate measurements and applied to study tetracycline absorption in humans after oral ingestion of 25, 50, 100, and 200-mg. doses. Calculation of absorption rate indicated that this drug was absorbed at a rate of about 100 to 140 mg./hr., one hour after 200-mg. doses, and at about 20 to 30 mg./hr., one hour later. Rates at these times decreased when the dose was reduced. Wide individual variation in absorption rate was observed among members of the test panel.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/JPS.3030490709","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 20
Abstract
A method was developed to calculate drug absorption rate from urinary excretion rate measurements and applied to study tetracycline absorption in humans after oral ingestion of 25, 50, 100, and 200-mg. doses. Calculation of absorption rate indicated that this drug was absorbed at a rate of about 100 to 140 mg./hr., one hour after 200-mg. doses, and at about 20 to 30 mg./hr., one hour later. Rates at these times decreased when the dose was reduced. Wide individual variation in absorption rate was observed among members of the test panel.
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