Programmable interactions with biomimetic DNA linkers at fluid membranes and interfaces

IF 19 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Reports on Progress in Physics Pub Date : 2019-03-31 DOI:10.1088/1361-6633/ab37ca
B. Mognetti, P. Cicuta, L. Di Michele
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引用次数: 27

Abstract

At the heart of the structured architecture and complex dynamics of biological systems are specific and timely interactions operated by biomolecules. In many instances, biomolecular agents are spatially confined to flexible lipid membranes where, among other functions, they control cell adhesion, motility and tissue formation. Besides being central to several biological processes, multivalent interactions mediated by reactive linkers confined to deformable substrates underpin the design of synthetic-biological platforms and advanced biomimetic materials. Here we review recent advances on the experimental study and theoretical modelling of a heterogeneous class of biomimetic systems in which synthetic linkers mediate multivalent interactions between fluid and deformable colloidal units, including lipid vesicles and emulsion droplets. Linkers are often prepared from synthetic DNA nanostructures, enabling full programmability of the thermodynamic and kinetic properties of their mutual interactions. The coupling of the statistical effects of multivalent interactions with substrate fluidity and deformability gives rise to a rich emerging phenomenology that, in the context of self-assembled soft materials, has been shown to produce exotic phase behaviour, stimuli-responsiveness, and kinetic programmability of the self-assembly process. Applications to (synthetic) biology will also be reviewed.
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可编程的相互作用与仿生DNA连接在流体膜和界面
生物系统的结构和复杂动力学的核心是由生物分子操作的特定和及时的相互作用。在许多情况下,生物分子制剂在空间上局限于柔性脂质膜,其中,除其他功能外,它们还控制细胞粘附、运动和组织形成。除了是几个生物过程的核心之外,受限于可变形基质的反应性连接物介导的多价相互作用是合成生物平台和先进仿生材料设计的基础。在这里,我们回顾了异质类仿生系统的实验研究和理论建模的最新进展,其中合成连接剂介导流体和可变形胶体单位(包括脂质囊泡和乳状液滴)之间的多价相互作用。连接体通常由合成的DNA纳米结构制备,使其相互作用的热力学和动力学性质完全可编程。多价相互作用的统计效应与基板流动性和可变形性的耦合产生了丰富的新兴现象学,在自组装软材料的背景下,已被证明会产生奇异的相行为、刺激响应性和自组装过程的动力学可编程性。应用(合成)生物学也将进行审查。
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来源期刊
Reports on Progress in Physics
Reports on Progress in Physics 物理-物理:综合
CiteScore
31.90
自引率
0.00%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Reports on Progress in Physics is a highly selective journal with a mission to publish ground-breaking new research and authoritative invited reviews of the highest quality and significance across all areas of physics and related areas. Articles must be essential reading for specialists, and likely to be of broader multidisciplinary interest with the expectation for long-term scientific impact and influence on the current state and/or future direction of a field.
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