Prognostic Role of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in the Survival of Patients with Esophageal Cancer

M. Tajik, Mohammad Shirkhoda, Maryam Hadji, Monireh Sadat Seyyed- salehi, E. Saeidi, K. Zendehdel
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Abstract

Background: Different factors can affect the future of a person with cancer. The patient’s systemic inflammatory response is an important factor. Several inflammatory markers have been evaluated for measuring the patient’s response to cancer. We evaluated neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as prognostic factors for survival in patients with pathologically proven esophageal cancer. Methods: In this retrospective cohort study, patients with pathologically approved esophageal cancer, who underwent surgical treatment in the cancer institute of Iran, were included. Demographic, pathological, and laboratory data of patients were obtained from the archive of medical records. Results: In this study, 135 patients with esophageal cancer with a mean age of 60 were studied. The median time of the follow-up period was 21 months. Mean NLR and PLR were 7.05 and 898, respectively. Patients’ survival had a significant relationship with their age, gender, tumor differentiation, receiving chemotherapy, absolute neutrophil count, total bilirubin, direct bilirubin, and NLR. Conclusion: According to the results, in a multivariable investigation, it was demonstrated that a high NLR has a direct effect on patients’ poor survival.
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中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值在食管癌患者生存中的预后作用
背景:不同的因素会影响癌症患者的未来。患者的全身炎症反应是一个重要因素。已经评估了几种炎症标记物来衡量患者对癌症的反应。我们评估了中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)作为病理证实的食管癌患者生存的预后因素。方法:在这项回顾性队列研究中,纳入了在伊朗癌症研究所接受手术治疗的病理批准的食管癌患者。患者的人口统计、病理和实验室数据均来自医疗档案。结果:本研究纳入135例食管癌患者,平均年龄60岁。中位随访时间为21个月。平均NLR和PLR分别为7.05和898。患者的生存与年龄、性别、肿瘤分化程度、是否接受化疗、中性粒细胞绝对计数、总胆红素、直接胆红素、NLR有显著关系。结论:根据结果,在一项多变量调查中,高NLR直接影响患者的不良生存。
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12 weeks
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