The protective role of some natural antioxidants against some nanoparticles-induced subchronic nephrotoxicity in Wistar rats

Abstract

The aim is to study the possible protection of fig fruit extract with olive oil and date-palm fruit extract (FOD) as natural antioxidants in decreasing the subchronic toxicity hazards of silicon oxide nanoparticles (SiO 2 NPs), aluminum oxide nanoparticles (Al 2 O 3 NPs), or zinc oxide nanoparticles (ZnONPs) in male rats treated for 75 days. We used 80 male Wistar rats distributed into 8 groups (n = 10) according to the experiment. We used various antioxidant treatments at their recommended antioxidant doses. All nanoparticles were given orally and daily for 75 days at doses of 100 mg/kg. The oral administration of different nanoparticles (NPs) alone led to dramatic histopathological features, a significant increase in the levels of the TBARS, tumor suppressor p53, and inflammatory markers (TNF-α and IL-6) in the renal tissue. In addition, serum kidney function parameters elevated significantly in NPs treated groups compared with the control group. On the other hand, the renal TAC, GSH, SOD, and TBARS lowered significantly in the renal tissue of rats administered with different NPs compared to the control group. The FOD-NPs-treated groups recorded significantly reduced nephrotoxicity effects as compared to the groups treated with NPs alone. In Conclusion , administration of FOD provides considerable protective effects against NPs-induced subchronic nephrotoxicity in male Wistar rats.