{"title":"Antitumor activity of Ailanthus excelsa (Roxb) stem bark fractions and Canthin-6-one","authors":"A. Said, K. Rashed, H. Tokuda, A. Huefner","doi":"10.18478/IUFSJB.60321","DOIUrl":null,"url":null,"abstract":"The alkaloidal compound was isolated from chloroform fraction of methanol 70% extract of Ailanthus excelsa stem bark of Egyptian origin. Successive extracts of A. excelsa stem bark and the isolated compound canthin-6-one were screened for chemopreventive activity. The chloroform extract showed strong inhibitory effect on short term in vivo assay for antitumor promotors, Epstein-Barr virus early antigen induction assay, compared with other fractions petroleum ether, diethyl ether and methanol 70% extracts. The isolated compound canthin-6-one also showed strong activity in the course of this assay. Further, these useful materials were investigated for the inhibitory effects in two-stage mouse skin carcinogensis test. Chloroform extract and its active canthin-6-one decrease actually the average number of papillomas per mouse and percentage papillomas in the promoting stage. These materials were found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogensis test.","PeriodicalId":14521,"journal":{"name":"IUFS Journal of Biology","volume":"51 1","pages":"1-6"},"PeriodicalIF":0.0000,"publicationDate":"2012-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IUFS Journal of Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18478/IUFSJB.60321","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
The alkaloidal compound was isolated from chloroform fraction of methanol 70% extract of Ailanthus excelsa stem bark of Egyptian origin. Successive extracts of A. excelsa stem bark and the isolated compound canthin-6-one were screened for chemopreventive activity. The chloroform extract showed strong inhibitory effect on short term in vivo assay for antitumor promotors, Epstein-Barr virus early antigen induction assay, compared with other fractions petroleum ether, diethyl ether and methanol 70% extracts. The isolated compound canthin-6-one also showed strong activity in the course of this assay. Further, these useful materials were investigated for the inhibitory effects in two-stage mouse skin carcinogensis test. Chloroform extract and its active canthin-6-one decrease actually the average number of papillomas per mouse and percentage papillomas in the promoting stage. These materials were found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogensis test.