K. Poulton, L. Kennedy, J. Ross, W. Thomson, J. Mbanya, W. Ollier
{"title":"A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon.","authors":"K. Poulton, L. Kennedy, J. Ross, W. Thomson, J. Mbanya, W. Ollier","doi":"10.1111/j.1744-313x.1998.tb01156.x","DOIUrl":null,"url":null,"abstract":"Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1744-313x.1998.tb01156.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.
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