Pub Date : 2002-01-01DOI: 10.1016/b978-012198382-6/50029-7
S. Marsh, E. Albert, W. Bodmer, R. Bontrop, B. Dupont, H. Erlich, D. Geraghty, J. Hansen, B. Mach, W. Mayr, P. Parham, E. Petersdorf, T. Sasazuki, G. Schreuder, J. Strominger, A. Svejgaard, P. Terasaki
{"title":"Nomenclature for factors of the HLA system, 2002.","authors":"S. Marsh, E. Albert, W. Bodmer, R. Bontrop, B. Dupont, H. Erlich, D. Geraghty, J. Hansen, B. Mach, W. Mayr, P. Parham, E. Petersdorf, T. Sasazuki, G. Schreuder, J. Strominger, A. Svejgaard, P. Terasaki","doi":"10.1016/b978-012198382-6/50029-7","DOIUrl":"https://doi.org/10.1016/b978-012198382-6/50029-7","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76551165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1016/s0198-8859(02)00367-1
S. Marsh
{"title":"Nomenclature for factors of the HLA system, update December 2001.","authors":"S. Marsh","doi":"10.1016/s0198-8859(02)00367-1","DOIUrl":"https://doi.org/10.1016/s0198-8859(02)00367-1","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75377943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-10-01DOI: 10.1034/J.1399-0039.2001.580412.X
S. Marsh
{"title":"Nomenclature for factors of the HLA System, update July 2001.","authors":"S. Marsh","doi":"10.1034/J.1399-0039.2001.580412.X","DOIUrl":"https://doi.org/10.1034/J.1399-0039.2001.580412.X","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86354332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mouse cytokine gene nucleotide sequence alignments, 2000. Part IV.","authors":"G J Laundy, J L Bidwell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-02-01DOI: 10.1046/J.1365-2370.2001.00228.X
D. Reviron, C. Foutrier, S. Guis, P. Mercier, J. Roudier
To investigate the association of HLA-DRB1 alleles with polymyalgia rheumatica (PMR) and rheumatoid arthritis (RA), 55 patients with PMR without giant cell arteritis, 203 patients with RA and 230 controls, all from the European population of Marseille, were HLA-DRB1 genotyped by PCR-SSO. HLA-DRB1*01 was significantly increased in both the PMR and RA groups compared to controls (35% versus 17%, Pc < 0.05, and 41% versus 17%, Pc < 0.001, respectively). HLA-DRB1*04 was significantly increased in the RA group compared to controls (48% versus 23%, Pc < 0.001) but not in the PMR group. HLA-DRB1*04 subtype frequencies were significantly different between PMR patients and RA patients. Shared epitope-positive HLA-DRB1*04 alleles (DRB1*0401, 0404, 0405, 0408) were significantly overrepresented in RA patients compared to PMR patients and shared epitope-negative HLA-DRB1*04 alleles were overrepresented in PMR patients compared to RA patients. In conclusion, in the Mediterranean population studied, HLA-DRB1*01 is associated with RA and PMR whereas HLA-DRB1*04 is associated with RA only.
{"title":"DRB1 alleles in polymyalgia rheumatica and rheumatoid arthritis in southern France","authors":"D. Reviron, C. Foutrier, S. Guis, P. Mercier, J. Roudier","doi":"10.1046/J.1365-2370.2001.00228.X","DOIUrl":"https://doi.org/10.1046/J.1365-2370.2001.00228.X","url":null,"abstract":"To investigate the association of HLA-DRB1 alleles with polymyalgia rheumatica (PMR) and rheumatoid arthritis (RA), 55 patients with PMR without giant cell arteritis, 203 patients with RA and 230 controls, all from the European population of Marseille, were HLA-DRB1 genotyped by PCR-SSO. \u0000 \u0000 \u0000 \u0000HLA-DRB1*01 was significantly increased in both the PMR and RA groups compared to controls (35% versus 17%, Pc < 0.05, and 41% versus 17%, Pc < 0.001, respectively). HLA-DRB1*04 was significantly increased in the RA group compared to controls (48% versus 23%, Pc < 0.001) but not in the PMR group. HLA-DRB1*04 subtype frequencies were significantly different between PMR patients and RA patients. Shared epitope-positive HLA-DRB1*04 alleles (DRB1*0401, 0404, 0405, 0408) were significantly overrepresented in RA patients compared to PMR patients and shared epitope-negative HLA-DRB1*04 alleles were overrepresented in PMR patients compared to RA patients. \u0000 \u0000 \u0000 \u0000In conclusion, in the Mediterranean population studied, HLA-DRB1*01 is associated with RA and PMR whereas HLA-DRB1*04 is associated with RA only.","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57629823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-02-01DOI: 10.1046/J.1365-2370.2001.00239.X
J. Naud, D. Gibson
A new allelic form of the human IgLC2 gene is described. The marker involves a T to C substitution in the C lambda 2 constant region gene, a silent substitution at amino acid coding position 178 (YAASSYLSL) and two substitutions in the 3'-flanking region. Analysis of IgLC2 alleles in a total of 60 individuals has indicated a frequency of 0.32 for the new allele, which has been designated IgLC2*B2. The *B1 and *B2 alleles encode T and C, respectively, at nucleotide position 212 in the IgLC2 coding region. Both the *B1 and *B2 alleles are found in individuals homozygous for the single-copy RFLP allele of IgLC2/IgLC3 (8 kb EcoRI). Knowledge of alleles of this marker will be important for studies on the expression of the IgLC2 and IgLC3 isotypes in normal and autoimmune lymphocyte populations, as the coding regions of the two isotypes differ only at this position. The marker will also be useful in further studies of linkage with other IgLV and IgLC markers and to establish possible correlations with susceptibility to autoimmune disorders.
{"title":"A new coding region polymorphism of human IgLC2","authors":"J. Naud, D. Gibson","doi":"10.1046/J.1365-2370.2001.00239.X","DOIUrl":"https://doi.org/10.1046/J.1365-2370.2001.00239.X","url":null,"abstract":"A new allelic form of the human IgLC2 gene is described. The marker involves a T to C substitution in the C lambda 2 constant region gene, a silent substitution at amino acid coding position 178 (YAASSYLSL) and two substitutions in the 3'-flanking region. Analysis of IgLC2 alleles in a total of 60 individuals has indicated a frequency of 0.32 for the new allele, which has been designated IgLC2*B2. The *B1 and *B2 alleles encode T and C, respectively, at nucleotide position 212 in the IgLC2 coding region. Both the *B1 and *B2 alleles are found in individuals homozygous for the single-copy RFLP allele of IgLC2/IgLC3 (8 kb EcoRI). Knowledge of alleles of this marker will be important for studies on the expression of the IgLC2 and IgLC3 isotypes in normal and autoimmune lymphocyte populations, as the coding regions of the two isotypes differ only at this position. The marker will also be useful in further studies of linkage with other IgLV and IgLC markers and to establish possible correlations with susceptibility to autoimmune disorders.","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57629834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-02-01DOI: 10.1046/J.1365-2370.2001.00233.X
J. García-Lozano, M. González-Escribano, A. Valenzuela, Alicia García, A. Nunez‐roldan
The presence of certain vitamin D receptor (VDR) genotypes has been associated with low bone mineral density (BMD) in elderly populations as well as with accelerated bone loss in patients with rheumatoid arthritis (RA). In the present study, VDR genotypes from 120 Spanish patients with RA were investigated. Three VDR gene polymorphisms (BsmI, ApaI and TaqI) were investigated using polymerase chain reaction followed by enzymatic digestion. The distributions of VDR allelic frequencies were similar in patients and controls and therefore no influence of VDR polymorphisms on rheumatoid arthritis susceptibility could be demonstrated. However, in an analysis of the clinical features of the different VDR-related genetic subgroups, the BB/tt genotype, defined by the BsmI and TaqI restriction site polymorphisms, was identified to be weakly associated with an early onset RA in female patients. This VDR genotype has been associated with a low BMD level in various studies. When patients were stratified according to the presence of the shared HLA epitope SE, it was found that SE + female patients bearing the BB/tt genotype showed the earliest disease onset. The mechanisms by which the VDR polymorphism is associated with RA is unknown, but they could be related to the immunoregulatory properties of vitamin D.
{"title":"Association of vitamin D receptor genotypes with early onset rheumatoid arthritis.","authors":"J. García-Lozano, M. González-Escribano, A. Valenzuela, Alicia García, A. Nunez‐roldan","doi":"10.1046/J.1365-2370.2001.00233.X","DOIUrl":"https://doi.org/10.1046/J.1365-2370.2001.00233.X","url":null,"abstract":"The presence of certain vitamin D receptor (VDR) genotypes has been associated with low bone mineral density (BMD) in elderly populations as well as with accelerated bone loss in patients with rheumatoid arthritis (RA). In the present study, VDR genotypes from 120 Spanish patients with RA were investigated. Three VDR gene polymorphisms (BsmI, ApaI and TaqI) were investigated using polymerase chain reaction followed by enzymatic digestion. The distributions of VDR allelic frequencies were similar in patients and controls and therefore no influence of VDR polymorphisms on rheumatoid arthritis susceptibility could be demonstrated. However, in an analysis of the clinical features of the different VDR-related genetic subgroups, the BB/tt genotype, defined by the BsmI and TaqI restriction site polymorphisms, was identified to be weakly associated with an early onset RA in female patients. This VDR genotype has been associated with a low BMD level in various studies. When patients were stratified according to the presence of the shared HLA epitope SE, it was found that SE + female patients bearing the BB/tt genotype showed the earliest disease onset. The mechanisms by which the VDR polymorphism is associated with RA is unknown, but they could be related to the immunoregulatory properties of vitamin D.","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83128963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-02-01DOI: 10.1046/J.1365-2370.2001.00234.X
M. Azzawi, V. Pravica, P. Hasleton, I. Hutchinson
{"title":"A single nucleotide polymorphism at position --109 of the RANTES proximal promoter.","authors":"M. Azzawi, V. Pravica, P. Hasleton, I. Hutchinson","doi":"10.1046/J.1365-2370.2001.00234.X","DOIUrl":"https://doi.org/10.1046/J.1365-2370.2001.00234.X","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87501460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-01-01DOI: 10.1034/j.1399-0039.2001.580411.x
S. Marsh
{"title":"Nomenclature for factors of the HLA system, update June 2001.","authors":"S. Marsh","doi":"10.1034/j.1399-0039.2001.580411.x","DOIUrl":"https://doi.org/10.1034/j.1399-0039.2001.580411.x","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74724425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-01-01DOI: 10.1016/s0198-8859(01)00366-4
S. Marsh
{"title":"Nomenclature for factors of the HLA System, update August 2001.","authors":"S. Marsh","doi":"10.1016/s0198-8859(01)00366-4","DOIUrl":"https://doi.org/10.1016/s0198-8859(01)00366-4","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76470096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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