{"title":"Bioadhesion and the dewetting transition","authors":"R. Bruinsma , E. Sackmann","doi":"10.1016/S1296-2147(01)01225-2","DOIUrl":null,"url":null,"abstract":"<div><p>The article discusses interferometric experiments carried out on a number of receptor/ligand (‘linker’) based bioadhesion systems. The aim was to quantitatively test the applicability of wetting theory to bioadhesion. In all cases phase-separation phenomena were observed, with highly heterogeneous adhesion disks, which is not consistent with a simple equilibrium wetting description. We present both theoretical and experimental evidence that these phenomena can be best understood in terms of two concepts: (I) a membrane-mediated linker–linker attraction, and (II) a linker-controlled dewetting transition.</p></div>","PeriodicalId":100307,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics","volume":"2 6","pages":"Pages 803-815"},"PeriodicalIF":0.0000,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1296-2147(01)01225-2","citationCount":"30","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1296214701012252","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 30
Abstract
The article discusses interferometric experiments carried out on a number of receptor/ligand (‘linker’) based bioadhesion systems. The aim was to quantitatively test the applicability of wetting theory to bioadhesion. In all cases phase-separation phenomena were observed, with highly heterogeneous adhesion disks, which is not consistent with a simple equilibrium wetting description. We present both theoretical and experimental evidence that these phenomena can be best understood in terms of two concepts: (I) a membrane-mediated linker–linker attraction, and (II) a linker-controlled dewetting transition.
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