{"title":"Maximum pull out force on DNA hybrids","authors":"Pierre-Gilles de Gennes","doi":"10.1016/S1296-2147(01)01287-2","DOIUrl":null,"url":null,"abstract":"<div><p>We discuss theoretically the force <em>F</em> between two colloidal particles, each of them carrying one single strand DNA. The two strands are complementary only on a finite sequence of (ℓ) consecutive base pairs. We define an adjustment length <em>ϰ</em><sup>−1</sup> (a few base pairs); in the adjustment regions near both ends of the paired region, the tension is still mainly on one single strand. But in the central part (for ℓ><em>ϰ</em><sup>−1</sup>) the two backbones are equally loaded. This leads to a rupture force <em>F</em><sub><em>c</em></sub> increasing linearly with ℓ for ℓ<em>ϰ</em><1, and saturating for ℓ<em>ϰ</em>>1.</p></div>","PeriodicalId":100307,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1296-2147(01)01287-2","citationCount":"37","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1296214701012872","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 37
Abstract
We discuss theoretically the force F between two colloidal particles, each of them carrying one single strand DNA. The two strands are complementary only on a finite sequence of (ℓ) consecutive base pairs. We define an adjustment length ϰ−1 (a few base pairs); in the adjustment regions near both ends of the paired region, the tension is still mainly on one single strand. But in the central part (for ℓ>ϰ−1) the two backbones are equally loaded. This leads to a rupture force Fc increasing linearly with ℓ for ℓϰ<1, and saturating for ℓϰ>1.
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