{"title":"Sugar-mimic Alkaloids from Faeces bombycis and Their Pronounced α-Glucosidase Inhibitory Activities","authors":"Jian-Yu Lin, Yihai Wang, Xiangjiu He","doi":"10.9734/ACSJ/2016/25834","DOIUrl":null,"url":null,"abstract":"A new sugar-mimic alkaloid, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidineN-glyoxylamide (1) and a novel natural sugar-mimic alkaloid, (2R,3R,4R)-2-[(S)-1,2-dihydroxyethyl]piperidine-3,4diol (2), as well as nine known compounds, were isolated and identified from Faeces bombycis. Compounds 1 and 2 showed remarkable inhibitory activity against α-glucosidase with the IC50 value of 1.9 and 6.2 μM, which were 93.4 and 28.6 potent folds than that of acarbose. The results showed that the sugar-mimic alkaloids from Faeces bombycis exhibit significant and reasonably broad range α-glucosidase inhibitory activity, which may be useful in the prevention of the postprandial hyperglycemia and provide new candidates for the treatment of diabetes mellitus.","PeriodicalId":7399,"journal":{"name":"American Chemical Science Journal","volume":"63 1","pages":"1-9"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Chemical Science Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/ACSJ/2016/25834","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
A new sugar-mimic alkaloid, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidineN-glyoxylamide (1) and a novel natural sugar-mimic alkaloid, (2R,3R,4R)-2-[(S)-1,2-dihydroxyethyl]piperidine-3,4diol (2), as well as nine known compounds, were isolated and identified from Faeces bombycis. Compounds 1 and 2 showed remarkable inhibitory activity against α-glucosidase with the IC50 value of 1.9 and 6.2 μM, which were 93.4 and 28.6 potent folds than that of acarbose. The results showed that the sugar-mimic alkaloids from Faeces bombycis exhibit significant and reasonably broad range α-glucosidase inhibitory activity, which may be useful in the prevention of the postprandial hyperglycemia and provide new candidates for the treatment of diabetes mellitus.
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