{"title":"Modeling complex biological systems: Tackling the parameter curse through evolution","authors":"P. Hogeweg","doi":"10.32942/osf.io/safm4","DOIUrl":null,"url":null,"abstract":"In this perspective paper we review a previously published evolutionary model of the lac-operon to argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so we can debug experimental and modeling artifacts.","PeriodicalId":12324,"journal":{"name":"Evolutionary Systems Biology","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evolutionary Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32942/osf.io/safm4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
In this perspective paper we review a previously published evolutionary model of the lac-operon to argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so we can debug experimental and modeling artifacts.