Interrelations of cytokine production levels in the mechanisms of inflammatory process regulation in patients with community-acquired pneumonia

Abstract

The aim of study was to study of cytokine production levels and their relationship in the mechanisms of regulation of the inflammatory process in community-acquired pneumonia. Materials and methods. The study was carried out in the period 2017–2020 based on the therapeutic department of the Municipal non-profit enterprise “City Clinical Multidisciplinary Hospital No. 25” of Kharkiv City Council. The study involved 34 adult patients with CAP aged 18 to 80 years (mean age 36.5±10.3). The control group consisted of 20 apparently healthy individuals (mean age 39.5±12.5). Levels of IL-17, IL-1Ra, TGFβ1, visfatin, adiponectin were determined by enzyme-linked immunosorbent assay. Results. Levels of IL-1 Ra and IL-17 in the group of patients with САP were 3.77±0.24 and 33.08±0.10 pg/ml, respectively. In the PРI group, the level of these indicators was probably higher (p<0.05) and was 2.53±0.13 and 28.17±0.53 pg/ml. The level of TGFβ1 in the group of patients with CAP was 24.54±0.55 ng/ml and was slightly higher than in the group of AHI (26.33±0.62 ng/ml). No differences were found between adiponectin levels in the AHI group and patients with CAP, as in the case of visfatin levels. The disappearance of relationships in the system of normal regulation of the inflammatory process between one pair of cytokines and their appearance between other pairs indicates a violation of regulatory mechanisms in patients with community-acquired pneumonia. Conclusions. The identified characteristics of the cytokine profile reflect the end of the phase of active inflammation in the lungs and the beginning of the phase of compensatory reactions. The findings suggest the importance of studying the cytokine profile in patients with community-acquired pneumonia, which will help to develop new approaches to predict the course of pneumonia, ways to correct metabolic disorders that develop in this condition, and will help identify risk groups for this pathology