The role of gold nanoparticles in anticancer activity

Murtadha M-Hussein A-kadhim, A-Kadhim, Ameer Jawad Hadi, Siham Adnan Abdulsada
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Abstract

To enhance the cellular uptake and chemotherapeutic efficacy of a current chemotherapeutic medication, a nanoparticle drug carrier technology has been designed. Due to their distinctive electrical and optical characteristics, gold nanoparticles (Au NPs) have recently demonstrated intriguing medical and military uses. In the event that they come into touch with a biological system, little is known about their biocompatibility. Metallic nanoparticles have been successfully utilized for a kind of biological applications. A drug delivery system known as Au – PEG – PAMAM – DOX was produced by conjugating the dendrimer with the anti-cancer chemical doxorubicin (DOX) via an amide bond. The amount of DOX released from Au – PEG – PAMAM – DOX at a natural pH was negligible, but this amount significantly increased in an environment with a weak acidic milieu, according to studies on the release of medicines from acellular sources. A research into the intracellular release of the medication was carried out with the assistance of confocal laser scanning microscopy (CLSM). Recently conjugation to the nanosystem, In vitro viability experiments revealed an increase in the associated DOX cytotoxicity that could not be attributable to carrier components. This indicates that the effectiveness of the DOX was increased. In light of this, it has been hypothesized that the newly created pH-triggered multifunctional Au NPs- DOX nanoparticle system could pave the way for a viable platform for the intracellular delivery of a range of anticancer medicines. In the current study, the common Au NPs synthesis techniques and their well-established uses in diverse needs, particularly in biological sensing applications.
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金纳米颗粒在抗癌活性中的作用
为了提高细胞对当前化疗药物的吸收和化疗效果,设计了一种纳米颗粒药物载体技术。由于其独特的电学和光学特性,金纳米颗粒(Au NPs)最近显示出有趣的医学和军事用途。如果它们与生物系统接触,人们对它们的生物相容性知之甚少。金属纳米颗粒已成功地应用于一类生物领域。一种称为Au - PEG - PAMAM - DOX的药物传递系统是通过酰胺键将树状大分子与抗癌化学物质阿霉素(DOX)偶联而产生的。Au - PEG - PAMAM - DOX在自然pH下释放的DOX量可以忽略不计,但根据对非细胞来源药物释放的研究,在弱酸性环境中,这一量显着增加。在共聚焦激光扫描显微镜(CLSM)的帮助下,对药物的细胞内释放进行了研究。最近与纳米系统结合,体外活力实验显示相关的DOX细胞毒性增加,这不能归因于载体成分。这表明DOX的有效性得到了提高。鉴于此,有人假设新创建的ph触发多功能Au NPs- DOX纳米颗粒系统可以为一系列抗癌药物的细胞内递送铺平道路。在目前的研究中,常见的Au NPs合成技术及其在不同需求中的广泛应用,特别是在生物传感应用中。
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