{"title":"Genetic Characterization of C-Terminal Region of SERA5 Gene in Isolates of Plasmodium vivax in Southwestern Iran","authors":"G. Shokoohi, A. Saadatnia, A. Abolghazi","doi":"10.52547/iem.8.2.177","DOIUrl":null,"url":null,"abstract":"Backgrounds: by sequencing In this study, 14 different isolates were identified among all samples, which were recorded in the World Gene Bank. The number of haplotypes among the 14 samples was 12. Also, there were 25 polymorphic nucleotide positions out of about 400 nucleotide sites. The ratio of non-synonymous to synonymous mutations (1.87094) and the amount of Tajima’s D (-0.57671) indicated the positive effect of natural selection on the genetic diversity of C-ter-minal region in the SERA5 gene. Conclusions: Considering the safety and relative immunogenicity of vaccines, in addition to performing clinical trials, a regional vaccine should be developed to overcome genetic variation and antigenic changes in proteins.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"35 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection Epidemiology and Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52547/iem.8.2.177","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Backgrounds: by sequencing In this study, 14 different isolates were identified among all samples, which were recorded in the World Gene Bank. The number of haplotypes among the 14 samples was 12. Also, there were 25 polymorphic nucleotide positions out of about 400 nucleotide sites. The ratio of non-synonymous to synonymous mutations (1.87094) and the amount of Tajima’s D (-0.57671) indicated the positive effect of natural selection on the genetic diversity of C-ter-minal region in the SERA5 gene. Conclusions: Considering the safety and relative immunogenicity of vaccines, in addition to performing clinical trials, a regional vaccine should be developed to overcome genetic variation and antigenic changes in proteins.
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