An Overview on Various Analytical Methods for Estimation of Atenolol and Amiodarone from its Bulk and Pharmaceutical Dosage Forms

Abstract

The main objective of this review is to unify and interpret widely scattered information of reported studies on potential, reliable and efficient analytical methodologies which can estimate Atenolol and Amiodarone separately. The information and suggested outlined below may facilitate and guide further needed studies to optimize the use of analytical techniques like High Performance Liquid Chromatography (HPLC), Bioanalytical Methods, UV Spectroscopy, Stability indicating RP-HPLC methods etc. for determination of Atenolol and Amiodarone in formulation. From the reviewed literature it is obvious that HPLC is a commonly available method of testing in pharmaceutical laboratory so this method should be of choice for complete determination of Atenolol and Amiodarone. Selection of analytical methods is determined by several factors such as speed, convenience, specificity, accuracy, precision, sensitivity, selectivity, cost, availability of instruments, technical expertise and the number of samples to be analyzed.