Ventriculography Modality in Detection and Evaluation of Cardiotoxicity in Breast Cancer Patients Receiving Chemotherapy

Indonesian Journal of Cancer Pub Date : 2022-12-28 DOI:10.33371/ijoc.v16i4.906

H. Lubis, Rafa Nabila Haifa, Rizky Yusfasari, Muhammad Zikri Agung Ramadhan

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Abstract

Background: Tumor-infiltrating lymphocytes (TILs), mainly CD4+ and CD8 + T cells, have been extensively described in anti-tumor immunity, and knowledge of CD4+ and CD8+ T lymphocytes’ interplay in mediating the control of tumor growth exists. We use the role of TILs in predicting the prognosis of cervical cancer patients and develop the discovery of new immunotherapy strategies that specifically target TILs.Methods: A systematic review of studies carried out a histopathological and immunohistochemical examination of TILs and an immunotherapy treatment.Results: 10 articles were selected for a systematic review. Expression of TILs was associated with the progression of NIS to cervical cancer. CD4+ and CD8+ TILs can determine the stage and prognosis of cervical cancer. TILs immunotherapy is effective for all cervical cancer patients. Combination chemotherapy with anti-TILs immunotherapy and combination therapy for PD-1 and TILs was found to have a better potential for cervical cancer therapy.Conclusions: TILs can be a prognostic biomarker and a marker to predict cervical cancer.

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脑室造影在乳腺癌化疗患者心脏毒性检测和评估中的应用

背景:肿瘤浸润淋巴细胞(tumor -浸润淋巴细胞，til)，主要是CD4+和CD8+ T细胞，在抗肿瘤免疫中被广泛描述，CD4+和CD8+ T细胞在调节肿瘤生长中的相互作用已经存在。我们利用TILs的作用来预测宫颈癌患者的预后，并开发新的针对TILs的免疫治疗策略。方法:系统回顾研究，对TILs进行组织病理学和免疫组织化学检查，并进行免疫治疗。结果:10篇文章入选系统评价。TILs的表达与NIS向宫颈癌的发展有关。CD4+和CD8+ TILs可以决定宫颈癌的分期和预后。TILs免疫疗法对所有宫颈癌患者都有效。化疗联合抗TILs免疫治疗和PD-1与TILs联合治疗具有更好的宫颈癌治疗潜力。结论:TILs可作为宫颈癌的预后生物标志物和预测标志物。

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Indonesian Journal of Cancer

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