Effect of the Succinic Salt of Diethylethanolamine Fumar Ester on Cognitive Functions of Laboratory Animals

V. Bolotova, I. A. Titovich, E. B. Shustov
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Abstract

The effect of succinic salt of diethylethanolamine fumaric ester on the cognitive abilities of male CBA mice and outbred male rats was studied. It was found that the test substance at doses of 10 and 75 mg/kg in the “Extrapolation escape task” test has a positive effect on the short-term and long-term memory of animals, contributing to the preservation and reproduction of the information received. In the “T-maze” test, the succinic salt of diethylethanolamine fumaric ester in both doses was superior, and in the “Extrapolation escape task” test, it had a comparable effect with the reference drug piracetam (dose 900 mg/kg).
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二乙基乙醇胺富马酯琥珀酸盐对实验动物认知功能的影响
研究了二乙基乙醇胺富马酸酯琥珀酸盐对CBA雄性小鼠和远交雄性大鼠认知能力的影响。在“外推逃逸任务”试验中发现,10和75 mg/kg剂量的试验物质对动物的短期和长期记忆都有积极的影响,有助于接收到的信息的保存和繁殖。在“t -迷宫”试验中,两种剂量的丁二酸盐富马酸二乙基乙醇胺酯均表现优异,在“外推逃逸任务”试验中,其效果与对照药物吡拉西坦(剂量900 mg/kg)相当。
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