{"title":"IL-17 and intestinal tumorigenesis","authors":"Wook-Jin Chae, Alfred L.M. Bothwell","doi":"10.1016/j.ddmec.2011.11.001","DOIUrl":null,"url":null,"abstract":"<div><p>IL-17 is an important proinflammatory cytokine<span> in autoimmune diseases. The constant presence of IL-17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL-17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL-17 in intestinal tumorigenesis may be an effective approach for treating cancer.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 3","pages":"Pages e79-e83"},"PeriodicalIF":0.0000,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.11.001","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676511000149","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL-17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL-17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL-17 in intestinal tumorigenesis may be an effective approach for treating cancer.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
