Association of Serum Gamma Glutamyl Transferase with the Parameters of Metabolic Syndrome

Abstract

Background: This study was conducted to investigate the relationship between serum GGT (gamma glutamyl transferase) level and the components of metabolic syndrome in Nepalese metabolic syndrome patients. Methods: Anthropometric data and blood pressure was recorded for 100 metabolic syndrome patients. The height, weight, and waist circumference were recorded, and fasting blood samples were analysed for blood glucose, triglyceride, high density lipoprotein (HDL) cholesterol and GGT level. Results: Waist circumference, systolic BP, diastolic BP, blood glucose, triglyceride, and HDL cholesterol were 102.17 ± 8.12 Cm, 130.16 ± 14.70 mmHg, 84.45 ± 11.48 mmHg, 128.2 ± 50.4 mg/dL, 205.6 ± 101.4 mg/dL and 53.9 ± 15.9 mg/dL respectively. The median (with IQR) serum GGT level was 41.5 IU/L (21.2, 71.7). GGT level showed significant positive correlation with diastolic BP (r=0.311, p=0.002) and negative with HDL cholesterol (r=-0.359, p<0.001). Conclusions: Metabolic syndrome patients have serum GGT level in the upper normal range, it correlates with some components of metabolic syndrome.