Synthesis and Antimicrobial Screening of Some New Thiazole Substituted 1,3,4-Oxadiazole Derivatives

Abstract

: In the present work the synthesis and antimicrobial activity of new thiazole substituted 1,3,4-oxadiazole derivatives was achieved. The reaction of different thioamides with ethyl 4-chloro-3-oxobutanoate (4-chloro ethyl acetoacetate) gave ethyl 2(2-arylthiazol-4yl)acetate , which on subse-quent reaction with hydrazine hydrate in absolute ethanol afforded 2-(2-arylthiazol-4-yl)acetohy-drazide. 2-(2-arylthiazol-4-yl) acetohydrazide on reaction with CS 2 and KOH in aqueous ethanol cyclized to form 5-((2-arylthiazol-4-yl)methyl)-1,3,4-oxadiazole-2-thiol. Finally, 5-((2-arylthiazol-4-yl) methyl)-1,3,4-oxadiazole-2-thiol were further treated with α -halo ketones at room temperature to afford the target compounds . Most of the compounds showed good antibacterial as well as antifungal activity. 4-chloro-3-oxobuta-noate; α -halo ketones; antibacterial and antifungal activity