Formulation and evaluation of Pioglitazone loaded Bovine serum albumin nanoparticles along with Piperine

Drug Invention Today Pub Date : 2013-09-01 DOI:10.1016/j.dit.2013.05.011

Bindu Madhavi Boddupalli , Prasad Masana , Ravinder Nath Anisetti , Siri Vennela Kallem , Bhavana Madipoju

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引用次数: 11

Abstract

Aim

To formulate and optimize the process parameters of Pioglitazone and Piperine loaded BSA nanoparticles. This will serve the purpose avoiding the adverse effects of Pioglitazone by combining with herbal principle, Piperine.

Methods

Modified desolvation and coacervation method was selected for the formulation of nanoparticles. Method of cross linking, concentration of glutaraldehyde and pH were optimized.

Results

BSA nanoparticles loaded with Pioglitazone and Piperine were prepared. The loading efficiency was found to be maximum (81.5 ± 1.7) with chemical cross linking at 10% of glutaraldehyde and in alkaline pH. The size of the nanoparticles was in nano range and minimum with cocervation at alkaline pH. The drug release was found to be sustained upto 24 h and was efficient with nanoparticles formed at alkaline pH due to more surface area for dissolution.

Conclusion

The formed BSA nanoparticles loaded with Piperine and Pioglitazone will be beneficial for the treatment of diabetes.

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吡格列酮载牛血清白蛋白纳米颗粒与胡椒碱的制备及评价

目的制备吡格列酮和胡椒碱负载的牛血清白蛋白纳米颗粒，并对其工艺参数进行优化。这将有助于避免吡格列酮与草药原理胡椒碱的不良反应。方法采用改进的脱溶-凝聚法制备纳米颗粒。对交联法、戊二醛浓度和pH进行了优化。结果制备了负载吡格列酮和胡椒碱的bsa纳米颗粒。结果表明，在10%戊二醛和碱性条件下，化学交联的负载效率最高(81.5±1.7)，纳米颗粒的尺寸在纳米范围内，在碱性条件下，纳米颗粒的尺寸最小，在碱性条件下形成的纳米颗粒由于具有更大的溶解表面积，因此药物释放持续时间长达24 h。结论制备的胡椒碱和吡格列酮纳米颗粒可用于糖尿病的治疗。

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Drug Invention Today

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