Cryopreservation of two pronuclear stage zygotes

Reviews in Gynaecological Practice Pub Date : 2005-03-01 DOI:10.1016/j.rigp.2004.10.001

Yasser Orief , Nikos Nikolettos , Safaa AL-Hassani

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引用次数: 6

Abstract

The German embryo protection law (Embryonenschutzgesetz, ESchG) does not allow embryo selection, but only selection at the pronuclear stage. Furthermore, only as many pronuclear stage zygotes are allowed to be selected as are planned to be transferred in the same cycle. This means that after pre-selection of, for example, three pronucleated zygotes, these three must be transferred on the same or the subsequent day. A second selection process is not allowed. Non-selected pronuclear stage zygotes are allowed to be cryopreserved for a subsequent transfer.

The same situation is present in other European countries such as Swizerland and Italy. it is illegal to cryopreserve an oocyte after fusion of the pronuclei (PN). The idea of these laws was to avoid ethical problems related to cryopreservation of surplus embryos or wastage of embryos, because these have, according to these laws, the status of individual persons.

The current situation initiates much interest in developing a refined method of cryopreserving human pronuclear zygotes. The following article will discuss that issue in details.

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两个原核期受精卵的低温保存

德国胚胎保护法(Embryonenschutzgesetz, ESchG)不允许胚胎选择，只允许在原核阶段进行选择。此外，只有计划在同一周期内转移的原核期受精卵才能被选中。这意味着在预选之后，例如，三个原核受精卵，这三个必须在同一天或第二天转移。不允许进行第二次选拔。未选择的原核期受精卵被允许冷冻保存以备后续移植。瑞士、意大利等其他欧洲国家也出现了同样的情况。冷冻保存原核融合后的卵母细胞是违法的。这些法律的想法是为了避免与冷冻保存多余胚胎或浪费胚胎有关的伦理问题，因为根据这些法律，这些都有个人的地位。目前的情况引起了人们对开发一种冷冻保存人类原核受精卵的改进方法的极大兴趣。下面的文章将详细讨论这个问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reviews in Gynaecological Practice

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